Biomerieux, Inc.

Hospices Civils De Lyon

Universite Claude Bernard – Lyon1

Université Claude Bernard

Université Claude Bernard Lyon I

Bioaster

Estelle Peronnet

Guillaume Monneret

François Mallet

Fabienne Venet

Alexandre Pachot

Julien Textoris

Elisabeth Cerrato

Benjamin Delwarde

Virginie Moucadel

Thomas Rimmelé

Laurence Vachot

A kit for in vitro measurement of a at least one IL7R gene transcript in a blood sample, including specific reagents for measuring the transcript, and a control sample calibrated to contain the IL7R gene transcript corresponding to the mean quantity measured in a pool of reference blood samples from human patients in a state of septic shock when reference blood samples are taken, or who were in a state of septic shock within 72 h after taking the reference blood samples, and who were known to have survived, and/or a calibrated to contain the quantity of an IL7R gene transcript corresponding to the mean quantity measured in reference blood samples from patients in a state of septic shock when the reference blood samples are taken, or who were in a state of septic shock within 72 h after taking the reference blood samples, and not to have survived.

Kit for assessing the risk of complications in patients with systemic inflammatory response syndrome (SIRS)

The invention concerns a method of in vitro or ex vivo evaluation of the risk of complications in a patient who has sustained an insult or an infection generating a systemic inflammatory response syndrome, the method being characterized in that it comprises the step of detecting, in a biological sample obtained from said patient, at least one transcript of the IL7R gene, as well as measuring, in vitro or ex vivo, the quantity of at least one transcript of the IL7R gene, in a biological sample from a patient who has sustained an insult or an infection generating a systemic inflammatory response syndrome, in order to evaluate the risk of complications, and in particular of mortality, in said patient. The invention also concerns kits for measuring, in vitro or ex vivo, the quantity of at least one transcript of the IL7R gene in a biological sample.

Method for assessing the risk of complications in patients with systemic inflammatory response syndrome (sirs)

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Lyons, France

Estelle Peronnet