International Flavors & Fragrances Inc.

Estela Espinos Ferri

Avelino Corma Canós

Sara Iborra Chornet

Ana Maria Collado Perez

James S Sharley

Ian R Baxendale

Isabelle Fernandez Fernandez

Jorge Sánchez Quesada

Francisco Gonell GÓMEZ

Disclosed is a chemical process of preparing dehydrohedione from Hedione via &#x3b1;-chlorination and elimination steps. The process can be conducted in a one-pot process or in a continuous reactor system. Accordingly, a simple and cost effective process of preparing cis-Hedione enriched products is developed through reduction of dehydrohedione in the presence of a chiral catalyst system.

Chemical process of preparing dehydrohedione

Amine-catalyzed formation of cyclic allylic nitro compounds via nitro-aldol reaction is disclosed. A greener solvent and a cheaper, more robust catalyst than in previous reports are used in the nitro-aldol reaction. After screening a range of catalysts the reaction is developed as a selective method of synthesis of &#x3b1;-dehydroherbac and the scope is demonstrated with a small collection of additional substrates.

Preparation of cyclic allylic nitro compounds

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Moncofar, Spain

Estela Espinos Ferri