Hologic, Inc.

Estefania Alvarez

Joseph A Stand, Iii

Shawn St Pierre

John Laviola

Stephen Grantz

Brian Stellmach

Shannon Marie Butler

Yuliya Mathis

Lori Fontaine

Michelle Dawn Lyman

Adam Kozak

Jaimee Robertson

Stephen Spiegelberg

Victor Manuel Solano Umaña

Joseph A Iii Stand

A biopsy site marker configured to expand upon deployment into a biopsy cavity, and visible under several different imaging modalities, comprises a superabsorbent hydrogel component and a radiopaque element. The hydrogel is in a compressed, dehydrated state prior to deployment to facilitate placement of the marker within the biopsy site, and thereafter expands upon deployment in the biopsy site. Such expansion limits migration of the site marker.

Biopsy site marker

Examples of the present disclosure describe systems and methods for the long-term, real-time active monitoring of a wireless implant. In aspects, a wireless biosensor may be implanted in a breast biopsy cavity. The biosensor may detect biochemical parameter data of the breast biopsy cavity and the human body. The biosensor may transmit the detected biochemical parameter data in real-time to a surveillance system wirelessly coupled to the biosensor. The surveillance system may then facilitate the evaluation of the biochemical parameter data. In examples, the evaluation may comprise detecting trends in a tumor's microenvironment, monitoring the progress of a treatment, or adjusting a treatment to tailor a personalized treatment.

Wireless active monitoring implant system

Disclosed biopsy markers are adapted to serve as localization markers during a surgical procedure. Adaptation includes incorporation of materials detectable under ultrasound during surgery, as well as features for co-registration with image guidance or other real-time imaging technologies during surgery. Such biopsy markers, when used as localization markers, improve patient comfort and reduce challenges in surgical coordination and surgery time. Additional disclosed biopsy markers are adapted to serve as monitoring and/or detection apparatuses. Localization of an implanted marker may be done with ultrasound technology. Ultrasound image data is analyzed to identify the implanted marker. A distance to the marker or a lesion may be determined and displayed. The determined distance may be a distance between the ultrasound probe and the marker or lesion, a distance between the marker or lesion and an incision instrument, and/or a distance between the ultrasound probe and the incision instrument.

Ultrasound localization system with advanced biopsy site markers

Disclosed biopsy markers are adapted to serve as localization markers during a surgical procedure. Adaptation includes incorporation of materials detectable under ultrasound during surgery, as well as features for co-registration with image guidance or other real-time imaging technologies during surgery. Such biopsy markers, when used as localization markers, improve patient comfort and reduce challenges in surgical coordination and surgery time. Additional disclosed biopsy markers are adapted to serve as monitoring and/or detection apparatuses, Localization of an implanted marker may be done with ultrasound technology. Ultrasound image data is analyzed to identify the implanted marker. A distance to the marker or a lesion may be determined and displayed. The determined distance may be a distance between the ultrasound probe and the marker or lesion, a distance between the marker or lesion and an incision instrument, and/or a distance between the ultrasound probe and the incision instrument.

A method of ablating a target body tissue, such as uterine endometrial lining tissue, includes applying an agent comprising HAuClto the target body tissue, wherein the HAuClhas a molecular size greater than 50 microns, and removing the agent comprising HAuClfrom the target tissue after ablation of the target tissue begins.

Ablation agent and methods of use

Examples of the present disclosure describe systems and methods for the long-term, real-time active monitoring of a wireless implant. In aspects, a wireless biosensor may be implanted in a breast biopsy cavity. The biosensor may detect biochemical parameter data of the breast biopsy cavity and the human body. The biosensor may transmit the detected biochemical parameter data in real-time to a surveillance system wirelessly coupled to the biosensor. The surveillance system may then facilitate the evaluation of the biochemical parameter data. In examples, the evaluation may comprise detecting trends in a tumors microenvironment, monitoring the progress of a treatment, or adjusting a treatment to tailor a personalized treatment.

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Marlborough, MA, United States of America

Estefania Alvarez