Consejo Superior De Investigaciones Cientificas

Tolsa, S.a.

Esperanza Benito Cano

Julio Santarén Romé

Eduardo Aguilar Díez

Antonio Álvarez Berenguer

Antonio Esteban Cubillo

Mercedes Alonso Giner

Nuria García García

Julio Guzmán Perote

Pilar Tiemblo Magro

Bernardo Herradon Garcia

Antonio Chana Lopez

Ana Montero Aguado

Julio SANTARÉN RomÉ

Antonio ÁLvarez Berenguer

Eduardo Aguilar DÍEZ

The present invention relates to a method for producing a compound that comprises a pseudolaminar silicate of natural origin, which is at least one clay of the paligorskite-sepiolite group, characterized in that said method comprises the following steps: defibrillating the microfiber bundles of the at least one clay in water; dispersing the defibrillated clay in an organic or inorganic liquid solvent until a stable gel is formed; adding to the dispersion at least one clay-surface-modifying agent; removing the solvent from the dispersion by means of a solid-liquid separation process and/or drying process; and deagglomerating the final compound until a powdered product is obtained. A further object of the present invention is the compound that can be obtained using said method, as well as the use of the compound as an additive or filler in composite polymeric materials in order to enhance the properties thereof, the composite polymeric material likewise being encompassed within the present invention.

Method for producing a compound based on pseudolaminar silicates and the use thereof as a filler for polymeric materials

The present invention relates to compounds derived from biphenyl with activity as calpain inhibitors. One compound of the present invention is a 2,2'-disubstituted biphenyl, where the substituents in the 2 and 2&#x2032; positions of the biphenyl skeleton are chains containing structures related to amino acids, including fragments of aminocarbonylic compounds where at least one of the substituents in said 2- or 2&#x2032;-positions is bonded to the biphenyl skeleton via a thiocarbonyl group, forming compounds with thioamide functionality. The present invention also encompasses any of the conformational isomers (atropisomers) of said compound of formula I. The compounds of formula I have application in the preventive or therapeutic treatment of a degenerative disease. 

Biphenyl derived thiamides as calpain inhibitors

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Esperanza Benito Cano