Orion-yhtyma Oy

Esko Veikko Marttila

Martti Lauri Marvola

Jaakko A Uotila

Erkki J Honkanen

Aino K Pippuri

Pekka J Kairisalo

Kari Vahervuo

Gunilla Margareta Orn

Ulla Inkeri Leinonen

Gunnar A Sothmann

Esa Petteri Lahdenpaa

Ilkka Larma

Reija Tuulikki Yrjola

Peroral composition for controlled release in the lower gastrointestinal

Gelatine capsule containing selegiline or derivative and paraffin as

The invention relates to a new composition for use on a pharmaceutical granule. The composition is three-layered, comprising as the innermost layer a substantially pure fat, as the middle layer a mixture of fat and polymer, and as the outermost layer again a substantially pure fat. The composition according to the invention produces a preparation which is tasteless, especially when administered in the form of a powder or a mixture, even if the phrmaceutical to be dosed has a bad taste. Also, the preparation keeps well in mixture, and it enables a pharmaceutical to be transported past the stomach for release/absorption at the beginning of the small intestine.

Composition for the oral administration of pharmaceuticals

The invention relates to a new antibiotic compound, acetyl erythromycin stearate having formula I ##STR1## The compound according to the invention is absorbed readily from the alimentary tract. Gastric acid does not convert the compound according to the invention to an uneffective form as is the case with some other erythromycin antibiotics. Absorbing is good also when the patient eats when taking the new medicine. The compound according to the invention is prepared by reacting erythromycin base with acetyl halide in an organic solvent in the presence of an acid acceptor. The stearate salt is prepared from the obtained ester without in between isolating the ester.

Acetyl erythromycin stearate, and compositions containing it

A process for the preparation of matrix-type tablets with retarded liberation of the active agent. The liberation of the active agent from the tablets takes place at a speed that has been adjusted precisely in advance. In the granulation process, polymethacrylate plastics insoluble in neutral or slightly acid water either as dissolved in an organic solvent or as a water dispersion are used as the retarding matrix substance. Before the tablets are compressed, an ester of a large-molecule fatty acid or a product obtained from same by means of hydrogenation is mixed into the grain mix in order to adjust the rate of liberation of the active agent.

Process for the preparation of tablets with retarded liberation of the

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Perttula, Finland

Esko Veikko Marttila