Teijin Limited

The University of Arizona

Nexstar Pharmaceuticals, Inc.

Gilead Sciences, Inc.

Eskild A Petersen

Richard T Proffitt

Su-Ming Chiang

Kevin R Bracken

Evan M Hersch

Yasuhiko Masuho

Evan M Hersh

Takashi Kawamura

Toru Sugano

Douglas Lake

Yoh-Ichi Matsumoto

Yoh-ichi Matsumoto

A liposomal aminoglycoside formulation comprising a neutral lipid, a negatively charged lipids and a sterol. The formulation contains unilamellar vesicles having an average size below 100 nm. A process of making liposomes containing an aminoglycoside is also provided. A method is also provided for the treatment of drug susceptible and drug resistant bacteria.

Antibiotic formulation and use for bacterial infections

A liposomal aminoglycoside formulation comprising a neutral lipid, a negatively charged lipid and a sterol. The formulation contains unilamellar vesicles having an average size below 100 nm. A process of making liposomes containing an aminoglycoside is provided. A method is also provide for the treatment of drug susceptible and drug resistant bacteria.

Human monoclonal antibodies which belong to the IgGl subclass and are specific for HIV are described. The monoclonal antibodies have potential for use in the diagnosis, prevention and therapy of HIV infection.

Monoclonal antibodies specific for HIV and the hybridomas for production

Antibiotic formulation and use for drug resistant infections

A liposomal aminoglycoside formulation comprising a neutral lipid, a negatively charged lipids and a sterol. The formulation contains unilamellar vesicles having an average size below 100 nm. A process of making liposomes containing an aminoglycoside is provided where the hydration temperature is significantly below the transition temperature of the formulation. A method for the treatment of drug susceptible and drug resistant bacteria.

Human monoclonal antibodies which belong to the IgG1 subclass and are specific for HIV are described. The monoclonal antibodies have potential for use in the diagnosis, prevention and therapy of HIV infection.

Human IgG1 monoclonal antibodies are produced by hybridoma ATCC HB10074 and bind to gp120 of HIV.

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Tucson, AZ, United States of America

Eskild A Petersen