Ge Healthcare Bio-sciences Ab

Esfir Lofman

Hanno Ehring

Lars C Andersson

Joakim Svensson

A method for determining the concentration of a chromatographic medium in a liquid slurry comprises the steps of: providing a column () having a top end () and a bottom end () and adapted to retain a chromatographic medium therein; introducing a defined volume of the slurry () into the column (); providing a liquid flow through the column () from the top end to the bottom end of the column to settle the chromatographic medium in the column; measuring the bed height of the consolidated chromatographic medium or a value related thereto; and determining from the measured bed height or value related thereto the concentration, or a value related to the concentration of the chromatographic medium in the slurry. A device for performing the method as well as the use of the method in packing of especially large scale columns are also disclosed.

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Uppsala, Sweden

Esfir Lofman