Orion Corporation

Esa Muttonen

David Paul Brown

Esko I Kauppinen

Wiwik Watanabe

Petri Ahonen

Matthew Egerton Young

Martin J Murphy

Jussi Haikarainen

Reijo Bäckström

Kari Sepp&auml;l&auml;

Jorma Jokiniemi

Mika Timmerbacka

Elizabeth Stares

Jorma Lehtonen

Jarkko Munukka

Juha Kurkela

Reijo Backstr&ouml;m

Riikka Hypp&ouml;la

Jukka Kaukonen

Veli Pekka Tanninen

Kari Seppala

Esko Kauppinen

Raoul JÄRVINEN

Riikka Hyppölä

Crystalline spherical inhalation particles incorporating a combination of two or more different active ingredients and a process for the preparation thereof. The particles have a narrow particle size distribution, rough surfaces and improved stability. The inhalation particles of the invention are particularly useful in the administration of a combination medicament, e.g. a combination of an anti-inflammatory agent and a bronchodilator, by inhalation in the treatment of asthma and other respiratory disorders.

Inhalation particles incorporating a combination of two or more active ingredients

Inhalation particles incorporating, in an individual particle, a combination of a &#x3b2;hd 2-agonist and a glucocorticosteroid in a predetermined and constant ratio, a process for the preparation thereof and pharmaceutical compositions comprising the inhalation particles. The particles have a narrow particle size distribution and are preferably in the form of spherical crystalline particles with a rough surface. The particles are particularly useful in the treatment of asthma and other respiratory disorders.

Combination particles for the treatment of asthma

A device for delivering a powdered medicament by inhalation comprises an air inlet passage having low pressure-drop and low turbulence for stabilizing air flow before aerosolization, a dosing cup in the region of reduced air velocity to delay aerosolization, a high pressure drop throat to generate a high velocity flow, a rapidly expanding diverging passage to create a free jet of air with high turbulence and an outlet passage having large cross-sectional area to control the rate of dissipation of the free jet. The device is simple yet capable of consistently providing uniform and effective powder aerosolization and deagglomeration over a variety of patient inhalation profiles.

Dry powder inhaler

A multiple-dose powder inhaler comprising an inhaler body defining a medicament container, an air channel, a mouthpiece, a rotatable metering drum with one or more peripheral dosing recesses and a dose counter for indicating the number of metered doses of medicament that have been dispensed from, or remain in, the medicament container. The inhaler is useful, for example, in the treatment of asthma.

Inhaler with a dose counter

The present invention relates to a method for preparing optically active enantiomers of &lsqb;&lsqb;4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl&rsqb;-hydrazono&rsqb;propanedinitrile (I), particularly (&minus;) enantiomer of (I). Furthermore, the invention relates to a novel crystalline polymorphic form of the (&minus;) enantiomer.

Method for obtaining pure enantiomers of a pyridazinone derivative

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Espoo, Finland

Esa Muttonen