Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Astra Aktiebolag

Aktiebolaget Astra

Agro-chemie

Erzsebet Szalay

Dezso Korbonits

Pal Kiss

Gergely Heja

Endre Palosi

Ida Szvoboda Nee Kanzel

Csaba Gonczi

Csaba Huszar

Laszlo Ledniczky

Attila Nemeth

Erzsebet Molnar Nee Bako

Ferenc Sperber

Karoly Ban

Ferenc Morasz

Istvan Bone

Erzsebet Szabo Nee Kardos

Sandor Garaczy

Karol Gyure

Gyorgy Mihalovics

Lajos T Nagy

Istvan Szekely

Bela Bertok

Tamas U Kallay

Gyorgy Lugosi

Vilmos Simonidesz

Laszlo Simandi

Istvan Jelinek

Geza Arvai

Gabor Besenyei

Peter Gyory

Zsuzsanna Nad

Zsuzsanna Kuruczne Ribai

Mihaly Su

Iidiko Buttkai

Arpad K Vari

Peter Gy Ri

Mihaly Sut

Peter Gyri

Ildiko Buttkai

Arpad Kvari

Ilona Santa Nee Singola

Marta Lugosi

The subject of our invention is the process for the preparation of the 1-(3,4-dimethoxyphenyl)ethanol of formula (I), by the reduction of 3,4-dimethoxyacetophenone of formula (II), characterized in that the carbonyl group of the 3,4-dimethoxyacetophenone of formula (II) is reduced by 1 mol of hydrogen under the conditions of catalytic hydrogenation.

Process for the preparation of 1-(3,4-dimethoxyphenyl)ethanol

Process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and

The present invention relates to a process for the preparation of compounds of general formula (I), wherein R stands for a straight chained C.sub.1-5 alkyl group substituted by a chlorine atom in the 2-position, and acid addition salts thereof, characterized by reacting a 3,5-dichloro-2-alkanone of general formula (V), wherein R is a defined above, with an inorganic thiocyamate, and a) converting the 3-thiocyanato-5-chloro-2-alkanone of general formula (IV), thus obtained, wherein R is as defined above, into 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (II), wherein R is as defined above, by gaseous hydrochloric acid in an organic solvent, hydrogenating the said compound in the presence of a metal catalyst in an organic solvent, or b) reacting said compound of general formula (IV) with an aqueous mineral acid and treating the 2-hydroxy-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (III), thus obtained with a halogenating agent, and hydrogenating the 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (II) thus obtained, wherein R is as defined above, in an organic solvent in presence of a metal catalyst, and optionally converting the 4-methyl-5-(2-chloroalkyl)-thiazole of general formula (I), wherein R is as defined above, thus obtained or a hydrochloride salt thereof, in a manner known per into another acid addition salt or setting free a compound of general formula (I), wherein R is a defined above, from its acid addition salt.

Process for the preparation of pharmaceutical compositions

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Budapest, Hungary

Erzsebet Szalay