Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag

Teva Gyógyszergyár Zárkörüen Müködö Részvénytársaság

Erzsebet Meszaros Sos

Csaba Szabo

Szabolcs Salyi

Judith Aronhime

Claude Singer

Vilmos Keri

Adrienne Kovacsne-Mezei

Viktor Gyollai

Sandor Janos Molnar

Tivadar Tamas

The present invention provides novel crystalline forms of ascomycin as well as processes for the preparation thereof and pharmaceutical compositions comprising such crystalline forms of ascomycin.

Ascomycin crystalline forms and preparation thereof

The invention relates to a process for the synthesis of Aztreonam. Specifically, the process entails hydrolyzing [3S-[3&#x3b1;(Z),4&#x3b2;]]-3-[[(2-amino-4-thiazolyl)[(1-t-butoxycarbonyl-1-methylethoxy)imino]acetyl]amino]-4-methyl-2-oxo-1-azetidinesulfonic acid (t-Bu Aztreonam) to form Aztreonam.

Preparation of Aztreonam

A process for preparing ondansetron by transamination of an ondansetron structural analog that can be readily prepared conveniently by a Mannich reaction is provided. The process represents an improvement upon known procedures for making ondansetron by transamination because of its rapid rate, selectivity and the ease with which the product can be isolated from the reaction mixture.

Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-YL)methyl]-4H-carbazol-4-one

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Debrecen, Hungary

Erzsebet Meszaros Sos