The Penn State Research Foundation

Erwin Vogler

Mark Kester

James H Adair

William Benjamin White

Carlo Pantano

Alan J Snyder

Christopher A Siedlecki

Sarah M Rouse

Jun Wang

Victor Ruiz-Velasco

Lawrence Sinoway

Alan Snyder

Christopher Siedlecki

Victor Hershey Medical Center Ruiz-Velasco

The present invention provides a method for the synthesis of unagglomerated, highly dispersed, stable core/shell nanocomposite particles comprised of preparing a reverse micelle microemulsion that contains nanocomposite particles, treating the microemulsion with a silane coupling agent, breaking the microemulsion to form a suspension of the nanocomposite particles by adding an acid/alcohol solution to the microemulsion that maintains the suspension of nanocomposite particles at a pH of between about 6 and 7, and simultaneously washing and dispersing the suspension of nanocomposite particles, preferably with a size exclusion HPLC system modified to ensure unagglomeration of the nanocomposite particles. The primary particle size of the nanocomposite particles can range in diameter from between about 1 to 100 nm, preferably from between about 10 to 50 nm, more preferably about 10 to 20 nm, and most preferably about 20 nm.

Unagglomerated core/shell nanocomposite particles

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University Park, PA, United States of America

Erwin Vogler