Institut National De La Sante Et De La Recherche Medicale

Centre National De La Recherche Scientifique

Université De Nantes

Université D'angers

Inserm (institut National De La Sante Et De La Recherche Medicale)

Centre Hospitalier Universitaire De Nantes

Nantes Université

Inserm

Erwan Mortier

Ignacio Anegon

Yannick Jacques

Agnès Quemener

Ariane Plet

Catherine Harb

Patricia Vusio

Jérôme Bernard

Sebastien Daniel Morisseau

Carole Guillonneau

Dihia Meghnem

The present invention relates to the stimulation of the IL-15Rbeta/gamma signalling pathway, to thereby induce and/or stimulate the activation and/or proliferation of IL-15Rbeta/gamma-positive cells, such as NK and/or T cells. Appropriate compounds include compounds comprising at least one IL-15Rbeta/gamma binding entity, directly or indirectly linked by covalence to at least one polypeptide which contains the sushi domain of the extracellular region of an IL-15Ralpha.

IL-15Rα sushi domain—IL-15 fusion proteins

The present relates to interleukin 15 (IL-15) antagonists and uses thereof, in particular for the treatment of autoimmune diseases and inflammatory diseases. In particular, the present invention relates to an IL-15 mutant polypeptide having the amino acid sequence as set forth in SEQ ID NO:1 wherein the leucine residue at position 45 is substituted by an aspartic acid residue, the asparagines residue at position 65 is substituted by a lysine residue and the leucine residue at position 69 is substituted by an arginine residue.

Uses of IL-15 antagonists for the treatment of autoimmune and inflammatory diseases

The present invention relates to specific interleukin-15 (IL-15) antagonist polypeptides and uses thereof for the treatment of inflammatory and auto-immune diseases. In particular, the present invention relates to a specific interleukin-15 (IL-15) antagonist polypeptide comprising i) a IL15-Ralpha sushi-containing polypeptide comprising an amino acid sequence having at least 80% of identity with the amino acid sequence of SEQ ID NO:1 ii) a linker and iii) an IL-polypeptide comprising the amino acid sequence having at least at least 80% of identity with the amino acid sequence of SEQ ID NO:4 provided that the glutamine (Q) residue at position 108 is mutated.

Specific interleukin-15 (IL-15) antagonist polypeptide and uses thereof for the treatment of inflammatory and auto-immune diseases

IL-15Ralpha sushi domain&#x2014;IL-15 fusion proteins

IL-15 mutant polypeptides as IL-15 antagonists and encoding nucleic acids

The present invention relates to the identification of an epitope in human Interleukin-15 (IL-15) that is responsible for binding to the interleukin-15 receptor &#x3b1;-chain. Two IL-15 regions are involved in the formation of this epitope: the first region (LLELQVISL, peptide 1) corresponds to a sequence located in the B helix and the second (ENLII, peptide 2 orENLIIL, peptide 2a) to a sequence located in helix C. Muteins displaying agonist or antagonist properties are described, and may be useful as therapeutic agents.

IL-15 mutants having antagonist activity

The present invention relates to the identification of an epitope in human Interleukin-15 (IL-15) that is responsible for binding to the interleukin-15 receptor &#x3b1;-chain. Two IL-15 regions are involved in the formation of this epitope: the first region (LLELQVISL, peptide 1) corresponds to a sequence located in the B helix and the second (ENLIL, peptide 2 orENLIIL, peptide 2) to a sequence located in helix C. Muteins displaying agonist or antagonist properties are described, and may be useful as therapeutic agents.

IL-15 mutants having agonists/antagonists activity

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Nantes, France

Erwan Mortier