Nobio Ltd.

Tel Aviv University

Hadasit Medical Research Services and Development Ltd.

Ramot University Authority for Applied Research and Industrial Development Limited

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Osnat Feuerstein

Hochman, Nira

Hochman, Jacob

Ofek, Itzhak

Weiss, Ervin

Ervin Weiss

Itzhak Ofek

Yoel Kashman

Nurit Beyth

Janina Goldhar

Nathan Zaltsman

Nathan Sharon

Abraham Domb

Zichria Zakay-Rones

Jacob Hochman

Michael Moshe Perez Davidi

Michael Perez Davidi

Yael Houri-Haddad

Ira Farber

Nira Hochman

The present invention relates to anti-microbially active micro and nanoparticles, compositions comprising same, and use thereof for inhibiting bacterial growth and biofilm formation on surfaces or devices, e.g., dental surfaces or devices. The present invention further discloses methods of making such anti-microbially active micro or nanoparticles.

Micro and nanoparticulate compositions comprising anti-microbially active groups

This invention relates to anti-microbial active particles, compositions and uses thereof for inhibiting bacterial growth on surfaces or devices. This invention further discloses methods of making such anti-microbial active particles.

Anti-microbial particles and methods of use thereof

A particle including at least one aliphatic polymer having anti-microbially active quaternary ammonium groups chemically bound thereto, is provided. The particle may be used to inhibit populations of microorganisms and biofilms. Also provided are methods for the preparation of such particles and uses thereof for the inhibition of microorganisms.

Antimicrobial nanoparticulate additives forming non-leachable sustained antimicrobial polymeric compositions

The present invention discloses a selective and a non-selective method and means of treating microbial diseases in local infections. The novel method comprising the step of emitting a beam of a blue light towards the tissue to be treated, wherein the beam is having a wavelength from 400 to 550 nanometers and further wherein the temperature of said tissue is not exceeding about 42&#xb0; C. along the procedure or immediately after it so that a selective phototoxic effect is exerted. A cost effective device for selectively or non-selectively exerting phototoxic effect by emitting a beam of blue light towards a tissue to be treated is also provided useful, especially for dental application.

Method and means for exerting a phototoxic effect of visible light on microorganisms

The present invention concerns the use as anti-viral agents of isolated fractions from berry juice of the plant genus. Two specific fractions are provided: (a) polymeric material having a molecular weight&#x2267;12,000; and (b) proanthocyanidins-containing fraction. Thus, the invention provides methods of treating a subject against a viral infection; the method comprises providing said subject with at least one of the above isolated fractions in an amount effective to prevent production of a viral infection in said subject. A specific and preferred viral infection according to the invention is an influenza virus infection.

Methods of treating viral infections using berry juice fractions

A non-food anti-microbial-adhesion and aggregation composition comprising a suitable carrier and an effective amount of an adhesion inhibitory fraction isolated from juice from berries of theplant genus. In an embodiment the anti-aggregation and adhesion fraction is isolated from cranberry juice. It is characterized as being polymeric and having a molecular weight &#x2267;14,000; an elemental analysis of carbon 43-51%, hydrogen 4-5%, no nitrogen, no sulfur and no chlorine; a nuclear magnetic resonance (NMR) line spectrum as set forth in FIGS.A andB; and an ultraviolet spectrum with an absorption peak at 280 nm in neutral or acidic pH solution which is absent in alkali solutions. This fraction exhibits adhesion inhibitory activity against P fimbriated bacteria, oral bacteria and

Anti-microbial-adhesion fraction derived from vaccinium

A non-food anti-microbial-adhesion and aggregation composition comprising a suitable carrier and an effective amount of an adhesion inhibitory fraction isolated from juice from berries of the Vaccinium plant genus. In an embodiment the anti-aggregation and adhesion fraction is isolated from cranberry juice. It is characterized as being polymeric and having a molecular weight &gE;14,000; an elemental analysis of carbon 43-51%, hydrogen 4-5%, no nitrogen, no sulfur and no chlorine; a nuclear magnetic resonance (NMR) line spectrum as set forth in FIGS.,A and,B; and an ultraviolet spectrum with an absorption peak at 280 nm in neutral or acidic pH solution which is absent in alkali solutions. This fraction exhibits adhesion inhibitory activity against P fimbriated bacteria, oral bacteria and

A non-food oral hygiene composition comprising a suitable carrier and an effective amount of an adhesion inhibitory fraction isolated from juice from berries of the Vaccinium plant genus. In a preferred embodiment the anti-aggregation fraction is isolated from cranberry juice. It is characterized as being polymeric and having a molecular weight .gtoreq.14,000; an elemental analysis of carbon 43-51%, hydrogen 4-5%, no nitrogen, no sulfur and no chlorine; an NMR line spectrum as set forth in FIGS. 2A and 2B; and an ultraviolet spectrum with an absorption peak at 280 nm in neutral or acidic pH solution which is absent in alkali solutions. This fraction exhibits adhesion inhibitory activity against both P fimbriated bacteria and oral bacteria.

Anti-oral-microbial adhesion fraction derived from vaccinium

Growing community of inventors

Herzeliya, Israel

Ervin Weiss