Ici Australia Limited

Other

Errol J McGarry

Bruce Adam Forsyth

Donald William Harney

Graham J Bird

David Ernest Pryor

Matthew Bolte

The invention relates to a process for the preparation of a compound of formula I ##STR1## R is alkyl, and X is bromine or iodine which process comprises: reacting a compound of formula II in a two phase system, said system comprising an aqueous phase and an organic phase comprising a water immiscible solvent, with an acylating agent of formula III or IV in the presence of a base catalyst. ##STR2##

Process for preparing benzonitriles

The invention concerns novel compounds selected from D,L-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]-thiazolium 4-cyano-2-iodo-6-nitrophenoxide and L-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]thiazolium 4-cyano-2-iodo-6-nitrophenoxide. The compounds are anthelmintics effective against both nematodes and trematodes and in further embodiments the invention provides processes for the preparation of the compounds of the invention, compositions comprising as active ingredient the compounds of the invention and processes for killing helminths using the compounds of the invention.

Compounds and compositions

The invention concerns a process for the preparation of .gamma.-unsaturated carboxylic acid methyl esters by reacting an allyl alcohol with an excess of trimethyl orthoacetate in the presence of an acidic catalyst. The process involves: the slow addition of the allyl alcohol to trimethyl orthoacetate heated to a temperature at or near its boiling point; removal of portion of the trimethyl orthoacetate from the reaction mixture by distillation; and heating the remaining reaction mixture at a temperature of 130.degree. to 160.degree. C. to complete the reaction.

Process for the preparation of .gamma.-unsaturated carboxylates

A process for killing internal parasites of warm blooded animals which process comprises treating the infected animal with an effective amount of a composition comprising as active ingredient a compound of the general formula I: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, are hydrogen, lower alkyl, lower alkenyl, lower alkanoyl, lower alkenoyl, aroyl or CH.sub.2 COOR.sup.4 wherein R.sup.4 is hydrogen or lower alkyl; B, C and D, which may be the same or different, are halogen, optionally substituted lower alkyl, optionally substituted aryl, lower alkenyl, lower alkoxy, hydroxy, cyano, nitro, or COR.sup.5 wherein R.sup.5 is hydroxy, lower alkoxy or NR.sup.6 R.sup.7 wherein R.sup.6 and R.sup.7, which may be the same or different, are hydrogen or lower alkyl; A, E, X, Y and Z, which may be the same or different, are hydrogen, halogen, optionally substituted lower alkyl, optionally substituted aryl, lower alkenyl, lower alkoxy, hydroxy, cyano, nitro, or COR.sup.5 wherein R.sup.5 is as hereinbefore defined; J and G, which may be the same or different, are hydrogen, lower alkyl, optionally substituted aryl, cyano, nitro or trichloromethyl or, together with the geminal hydrogen, the group .dbd.CCl.sub.2 ; or an optical isomer thereof; or a salt thereof; and wherein lower alkyl and lower alkoxy are defined as groups containing from 1 to 6 carbon atoms, lower alkenyl and lower alkanoyl are defined as groups containing from 2 to 6 carbon atoms and lower alkenoyl is defined as a group containing from 3 to 6 carbon atoms; and an inert carrier therefor.

2,6-Benzyl substituted phenols

Treatment of animals with 2,6-bis(2-hydroxybenzyl)phenols to eradicate

A composition of matter for treating warm-blooded animals to eradicate internal parasites comprising a compound chosen from the group consisting of

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Bundoora, Australia

Errol J McGarry