Cytrx Corporation

Ernö Duda

László Ürögdi

Gábor Balogh

Ede Márványos

Ibolya Horváth

Péter Literáti Nagy

Mária Kürthy

László Vígh

Zsolt Török

Beatrix Farkas

Andrea Jednákovits

Attila Glatz

György Dormán

Katalin Bíró

László Korányi

Éva Udvardy

Dénes Medzihradszky

Bea Mézes

Eszter Kovács

László Jaszlits

Jenö Szilbereky

Mihály Barabás

Erzsébet Hegedüs

A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.

Method of enhancing cellular production of molecular chaperone, hydroxylamine derivatives useful for enhancing the chaperone production and the preparation thereof

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Budapest, Hungary

Ernö Duda