Ucb S.a.

Hunter-fleming Limited

Ucb Societe Anonyme

Ernst Wulfert

Jean Gobert

Eric Cossement

Philippe Michel

Berend Jan Van Keulen

Solo Goldstein

Alex Bollen

Jean-Pierre Jules Geerts

James Robert Murray

Ashley Ker Pringle

Alma Gower

David Wynick

Lars Eric Sundstrom

A steroid derivative compound of formula (I) in which: one of Rand Ris hydroxy and the other is hydrogen; or Rand Rtogether represent oxo; Ris hydrogen or hydroxy; and the dotted lines represent single or double carbon-carbon bonds; and pharmaceutically acceptable salts and esters thereof are useful for the prevention or treatment of pain, for improving nerve regeneration after nerve injury or damage or disease, for the prevention or treatment of brain injury, damage or disease and for neuroprotection. Particularly useful compounds are 11-hydroxy-&#x394;4-androstene-3,17-dione and 11-oxo-&#x394;4-androstene-3,17-dione or their derivatives. 

Therapeutic uses of steroidal compounds

3-Hydroxy-7-hydroxy steroids and 3-oxo-7-hydroxy steroids, especially the 7&#x3b2;-isomers thereof, and pharmaceutically acceptable esters thereof are useful for protection against ischaemia-induced damage to peripheral organs, such as the heart or kidneys, as well as treatment of spiral cord injury.

Phophylactic and therapeutic use of hydroxysteroids

7-Hydroxyepiandrosterone may be used for protection against acute or chronic neuronal damage.

7-hydroxyepiandrosterone having neuroprotective activity

A method is disclosed for the treatment of anxiety in a patient in need thereof, by administering to said patient an effective amount of (S)-(-)-.alpha.-ethyl-2-oxo-1-pyrrolidineacetamide of the formula ##STR1##

Treatment of anxiety with the aid of

New 2-hydroxyl-3-[1-(1H-imidazol-4-yl)alkyl]-benzenecarboximidamides as well as their salts, having the formula ##STR1## wherein R.sub.1 is hydrogen or an alkyl radical having 1 to 4 carbon atoms,

Hydroxy-3-[1-(1H-imidazol-4-yl)alkyl]-benzenecarboximidamides and their

New substituted cyclopropylamino-1,3,5-triazines having the formula ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.3 -alkyl, C.sub.3 -C.sub.5 -cycloalkyl or C.sub.1 -C.sub.3 -alkyl-C.sub.3 -C.sub.5 -cycloalkyl

Substituted cyclopropylamino-1,3,5-triazines

The present invention provides recombinant DNA sequences comprising a sequence which codes for human proapolipoprotein A-I wherein part of the natural coding sequence has been replaced by a DNA fragment coding for the same amino acids but consisting of a different nucleotide sequence such as to reduce or prevent formation of hairpins, cloning and expression vectors containing these DNA sequences, cell cultures or microorganisms transformed with these expression vectors and processes using the same for the production of proapolipoprotein A-I.

Expression of human proapolipoprotein A-I

A method for the treatment of cognitive and behavioral disorders associated with aging and with dementia syndromes, for example senile dementia, Alzheimer's type, by administering a 2-amino-4-morpholino-6-propyl-1,3,5-triazine of the formula ##STR1## in which R.sub.1 =hydrogen, alkyl, aralkyl or acetyl, R.sub.2 =hydrogen, hydroxyl, alkyl, hydroxyalkyl, alkoxyalkyl, dialkylamino, aryl-hydroxyalkyl, (hydroxycycloalkyl)alkyl, alkanoyloxyalkyl, benzoyloxyalkyl, phenylacetyloxyalkyl, aminocarbonyloxyalkyl, COR.sub.3, where R.sub.3 =alkyl, aryl, halogenoaryl, alkylaryl, alkoxyaryl, aralkyl or aryloxy, CONR.sub.4 R.sub.5, where R.sub.4 and R.sub.5 =hydrogen or alkyl, or R.sub.1 and R.sub.2 form an alkyleneimino substituted by hydroxyalkyl, and in addition when R.sub.1 =acetyl, R.sub.2 =acetoxyalkyl, or a salt thereof.

Treatment of cognitive and behavioral disorders associated with aging

New substituted 1-(1H-imidazol-4-yl)alkyl-benzamides and their salts, processes for the preparation thereof and pharmaceutical compositions. These compounds have the formula ##STR1## wherein R.sub.1, R.sub.2 =hydrogen or C.sub.1 -C.sub.4 -alkyl,

Growing community of inventors

Brussels, Belgium

Ernst Wulfert