Noxilizer, Inc.

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Amulet Pharmaceuticals, Inc.

Ernst V Arnold

Blaine G Doletski

Robert E Raulli

Larry K Keefer

Joseph A Hrabie

Karen R Benedek

Thomas M Dunn

Edward P Mueller

Marie-Louise Murville

A system, device and method for sterilizing or decontaminating an object that by exposing the object to a sterilant gas comprised of one or more oxides of nitrogen, such as NO, NO, NO, NO, NO, NO, NO and mixtures thereof. The source of the sterilant gas can be generated from a sterilant gas-generating composition or provided by a source of the sterilant gas.

Sterilization system and device

This invention relates to compositions comprising carbon-based diazeniumdiolates attached to hydrophobic polymers that releases nitric oxide (NO). The carbon-based diazeniumdiolated polymers release NO spontaneously under physiological conditions without subsequence nitrosamine formation. The present invention also relates to methods of preparing the carbon-based diazeniumdiolated polymers, compositions comprising such polymers, methods of using such compositions, and devices employing such polymer compositions.

Nitric oxide-releasing polymers

This invention relates to compositions comprising carbon-based diazeniumdiolates that release nitric oxide (NO). The carbon-based diazeniumdiolated molecules release NO spontaneously under physiological conditions without subsequent nitrosamine formation. The present invention also relates to methods of preparing the carbon-based diazeniumdiolated molecules, compositions comprising such molecules, methods of using such compositions, and devices employing such molecule compositions.

Nitric oxide-releasing molecules

This invention relates to compositions comprising carbon-based diazeniumdiolates attached to hydrophobic polymers that releases nitric oxide (NO). The carbon-based diazeniumdiolated polymers release NO spontaneously under physiological conditions without subsequent nitrosamine formation. The present invention also relates to methods of preparing the carbon-based diazeniumdiolated polymers, compositions comprising such polymers, methods of using such compositions, and devices employing such polymer compositions.

The present invention relates to nitric oxide-releasing amidine diazeniundiolates, compositions comprising same, methods of using same, and a method for preparing same from imidate diazeniumdiolates and primary or secondary amines.

Nitric oxide-releasing amidine diazeniumdiolates, compositions and uses thereof and method of making same

The invention provides NO- or NO-releasing imidate; and thioimidate, diazeniumdiolates, in which the NOfunctional group is bonded to a carbon atom. The imidate and thioimidate diazeniumdiolates are bound to a polymer or a substrate.

Nitric oxide-releasing imidate and thioimidate diazeniumdiolates

The present invention relates to nitric oxide-releasing amidine diazeniumdiolates, compositions comprising same, methods of using same, and a method for preparing same from imidate diazeniumdiolates and primary or secondary amines.

The invention provides NO&mdash; or NO -releasing imidate, thioimidate, and amide diazeniumdiolates, in which the N O functional group is bonded to a carbon atom. The invention also provides compositions comprising such diazeniumdiolate compounds, and methods of using such compounds and compositions. The invention further provides a method of preparing NO&mdash; or NO -releasing imidate, thioimidate, and amide diazeniumdiolates.

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Hagerstown, MD, United States of America

Ernst V Arnold