Boehringer Ingelheim Gmbh

Dr. Karl Thomae Gesellschaft MIT Beschrankter Haftung

Ernst Seeger

Wolfhard Engel

Gunter Trummlitz

Gunther Engelhardt

Helmut Teufel

Josef Nickl

Walter Haarmann

Rainer Zimmermann

Wolfgang Eberlein

Gunther Schmidt

Joachim Kahling

Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, methyl, methoxy, fluorine or chlorine; and

Antithrombotic

Compounds of the formula ##STR1## wherein X is oxygen or sulfur;

Condensed isothiazolo-3 (2H)-one-1-1-dioxides

There are described pharmaceutical compositions containing as active substances benzothiazol-2(3H)-ones of the general formula ##STR1## wherein R represents a hydrogen atom or a methyl, methoxy, or ethoxy group. The pharmaceutical compositions serve as analgesics and antipyretics and possess little or no methemoglobin-forming activity.

Suppressing pain with benzothiazol-2(3H)-ones

Compounds of the formula ##STR1## wherein Ar is phenyl; mono- or di-substituted phenyl, where the substituents are one to two halogens, one to two alkyls of 1 to 3 carbon atoms, or one amino, nitro, cyano or trifluoromethyl; or pyridinyl;

2-[(Amino)-aryl-methylene]-benzo[b]thiophen-3(2H)-ones

Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, halogen or alkyl of 1 to 3 carbon atoms; R.sub.2 is hydrogen or alkyl of 1 to 3 carbon atoms; and

4-Hydroxy-2H-[1]-benzothieno

4,5-Dimethyl-thieno[3,2-d]isothiazolo-3(2H)-one-1,1-dioxides,

Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, methyl or ethyl;

4-Hydroxy-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxides and salts

Compounds of the formula ##STR1## WHEREIN R.sub.1 is hydrogen, methyl or ethyl;

2,5-Dihydro-1,2-thiazino(5,6-b)indole-3-carboxamide-1,1-dioxides and

Compounds of the formulas ##STR1## and ##STR2## wherein A is --CH.sub.2 -- or --CH(OH)--,

Derivatives of 4-(4-biphenylyl)-butyric acid

Compounds of the formula ##STR1## wherein R is hydrogen or alkyl of 1 to 4 carbon atoms, and, when R is hydrogen, non-toxic salts thereof formed with an inorganic or organic base; the compounds as well as the salts are useful as antiphlogistics and antiproliferatives.

4-(2'-Fluoro-4-biphenylylr-4-oxo-butyric acid and esters and salts

Compounds of the formula ##SPC1## Wherein

4-Hydroxy-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxides and

3-(2'-Fluoro-4-biphenylyl)-butyric acid and salts thereof formed with inorganic or organic bases; the compound as well as its salts are useful as antiphlogistics and antirheumatics.

3-(2'-Fluoro-4-biphenylyl)-butyric acid and salts thereof

Compounds of the formula ##SPC1## Wherein A is ##EQU1## or WHERE Z is hydrogen or methyl, and

(4-Biphenylyl)-butenols

Compounds of the formula formula ##EQU1## wherein R.sub.1 is chlorine or fluorine, and R.sub.2 is hydrogen, alkanoyl of 1 to 10 carbon atoms, benzoyl, nicotinoyl or isonicotinoyl, Or, when R.sub.2 contains a basic nitrogen atom, a non-toxic, pharmacologically acceptable salt thereof formed with an inorganic or organic acid; the compounds as well as the salts are useful as antiphlogistics.

3-(2-Halo-4-biphenylyl)-1-butanols and derivatives thereof

Pharmaceutical compositions containing a compound of the formula ##SPC1## Wherein

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Biberach, Germany

Ernst Seeger