Bracco Diagnostics Inc.

Bracco International Bv

Bracco Suisse Sa

Ernst Schramm

Ernest Balestracci

Julius P Zodda

Michael N Eakins

Jo Anna Monteferrante

John J Niedospial, Jr

Charles R Quirico

James A Melchore, Jr

Irene K Ropiak

James A Melchore

Rama K Narra

Margaret Newborn

Irene Ropiak

Edmund C Metcalfe

Bruce Kuczynski

Gregory W White

John J Niedospial Jr

Irene Kucharewicz Ropiak

Gregory White

Jules Zodda

A radioisotope generator system can include a column assembly having a column, an inlet arm, an outlet arm. The column can contain packing material that binds a radioisotope. In addition, the column may define a notch between an open area and a stopper receptacle area in which an opening of the outlet arm is positioned. In some examples, the system includes a Luer lock connection between the outlet arm and a connector tubing. The Luer lock connection can include a male Luer cap and a female Luer cap each comprising tabs configured to line up with or overlap each other so as to indicate when the caps are sufficiently tightened together so as to form a non-leaking lock.

Containers for pharmaceuticals, particularly for use in radioisotope generators

The invention is directed to improved containers for pharmaceuticals and any tubing and tubing connectors associated therewith, particularly containers for pharmaceuticals which are irradiated, heated or otherwise subjected to increased pressure. In a preferred embodiment, the invention is directed to an improved container for use in a radioisotope generator, such as a rubidium-82 generator.

A prefilled syringe of cartridge barrel having a tamper evident closure. Tamper evidence is provided by: a frangible tip seal which is integral with the tapered tip of the barrel; a frangible tip cap covering the tip, the tip seal and a portion of the distal end of the barrel; and an overwrap covering the frangible tip cap and the distal end of the barrel sealed to the distal end of the barrel by a tamper evident seal. The tapered tip is optionally equipped with a luer collar to receive an external luer connector. Alternatively, the tapered tip can be provided with a bore therethrough which can be closed with an elastomeric plug and the external connector can be a tubing conduit.

Tamper evident syringe barrel

The invention features sincalide formulations that include an effective amount of sincalide, a bulking agent/tonicity adjuster, a stabilizer, a surfactant, a chelator, and a buffer. The invention also features kits and methods for preparing improved sincalide formulations, as well as methods for treating, preventing, and diagnosing gall bladder-related disorders using sincalide formulations.

Sincalide formulations

Manufacturing process to control particle size

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Milltown, NJ, United States of America

Ernst Schramm