Actinium Pharmaceuticals, Limited

Ernst Huenges

Josue Manuel Moreno Bermudez

Richard Henkelmann

Eva Kabai

Andreas Turler

Michael Schilp

Mark Harfensteller

The present invention describes a method for purification ofAc from irradiatedRa-targets provided on a support comprising a leaching treatment of theRa-targets for leaching essentially for the entirety ofAc andRa with nitric or hydrochloric acid, followed by a first extraction chromatography for separatingAc fromRa and other Ra-isotops and a second extraction chromotography for separatingAc fromPo andPb. The finally purifiedAc can be used to prepare compositions useful for pharmaceutical purposes.

Method for purification of 225AC from irradiated 226RA-targets

The present invention describes a method for purification ofAc from irradiatedRa-targets provided on a support, comprising a leaching treatment of theRa-targets for leaching essentially the entirety ofAc andRa with nitric or hydrochloric acid, followed by a first extraction chromatography for separatingAc fromRa and other Ra-isotops and a second extraction chromatography for separatingAc fromPo andPb. The finally purifiedAc can be used to prepare compositions useful for pharmaceutical purposes.

The present invention refers to a method for producing a radium target for the production of radionuclides by means of accelerated protons, whereby at least one radium containing material out of an aqueous-organic solution or suspension of such a material is applied by means of a dispersing device on a surface in such a way that the dispersing device and the surface are moving relatively towards each other and that the solvent is removed substantially spontaneously. Further, the invention refers to a radium target that is created in such a way that it may exhibit an activity of up to 1.5 curie. The radium targets according to the present invention serve for the production of the radionuclideAc, which may be used in nuclear medicine in the treatment of cancer, particularly in form of its daughter nuclideBi.

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Garching, Germany

Ernst Huenges