Egyt Gyogyszervegyeszeti Gyar

Egis Gyogyszergyar Rt.

Biogal Gyogyszergyar Rt.

Biogal Gyogyszergyar

Florin Vegyipari Szovetkezet

Erno Orban

Imre Moravcsik

Tibor Balogh

Antal Simay

Gyula Horvath

Istvan Elekes

Tamas Hamori

Gabor Ambrus

Sandor Elek

Jeno Korosi

Peter Botka

Janos Borvendeg

Laszlo Nagy

Sandor Jancso

Gyorgy Bacsa

Antonia Jekkel

Gyorgy Somogyi

Katalin Marossy

Istvan Kovacs

Jozsef Lango

Lajos Ila

Eva Tomori

Eva T Sarudy

Lajos Siklosi

Peter Varnai

Katalin Beke

Tibor Mathe

Judit Szilagyi

Margit Simo

Dorottya Bobak

Levente Szendrei

Margit Biblo

Csilla Kiss

Maria Bidlo Nee Igloi

Nee Dievald Uskert

Roozsa Gyenge

Erzsebet Bander

Marta Sotinee Tolvay

Process for the preparation of a tablet or dragee composition containing

The invention relates to a process for the preparation of 1-(3-chlorophenyl)-4-methyl-7,8-dimethoxy-5 H-2,3-benzodiazepine of formula (I) ##STR1## in high purity and in a quality suitable for pharmaceutical purposes. According to the invention the reaction of 1 mole of 2-acetonyl-3'-chloro-4,5-dimethoxybenzophenone of formula (II) ##STR2## with 3-7 moles of hydrazine hydrate in an organic solvent or in a mixture of organic solvents at a temperature between 15.degree. C. and 85.degree. C. is carried out in the absence of air oxygen, optionally in the presence of water. The crude product is then recrystallized from an aliphatic alcohol containing 1 to 5 carbon atom(s).

Process for the preparation of high-purity

The invention relates to a novel oil-in-water type cream containing aluminum potassium sulfate, which is useful for the treatment of varicosity. The composition of the invention contains 1 to 15% by weight of pharmaceutically acceptable lipid-type ointment base, 0 to 10% by weight of aluminum potassium sulfate dissolved in water, 10 to 80% by weight of propylene glycol and 0.1 to 5.0% by weight of cetyltrimethylammonium bromide and/or cetyltrimethylammonium chloride as emulsifying agent.

Cream containing aluminum potassium sulfate and process for preparing

The present invention relates to an intravenous pharmaceutical composition comprising cyclosporin as active ingredient. The composition is composed of

Intravenous pharmaceutical composition and process for preparing the same

Pharmaceutical compositions for sustained release of pharmaceutical compounds comprising a reaction product of a water soluble salt of a pharmaceutically active compound containing a primary, secondary or tertiary amino group, and an alkali or ammonium salt of a synthetic copolymer containing an acid group, and selected from the group consisting of methacrylic acid/methacrylic acid methyl ester, methacrylic acid/acrylic acid methyl ester and methacrylic acid/acrylic acid methyl ester/methacrylic acid methyl ester copolymers and a pharmaceutically acceptable excipient. The water soluble salt of a pharmaceutically active compound containing a primary, secondary or tertiary amino group is reacted in aqueous medium with an alkali or ammonium salt of a copolymer selected from the group consisting of the above mentioned copolymers, and the resulting product is converted into a pharmaceutical composition.

Sustained release pharmaceutical compositions

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Budapest, Hungary

Erno Orban