University of Tennessee Research Foundation

University of Memphis Research Foundation

US Government As Represented by the Secretary of the Army

Erno Lindner

Edward Chaum

Jidong Guo

Kenneth C Curley

The invention relates to a method for the controlled delivery of a drug as a function of bioavailable drug concentration, a sensor device for detecting bioavailable drug concentration, and a delivery device that controls delivery of the drug based on the real-time detection of bioavailable drug concentration.

Method and device for detection of bioavailable drug concentration in a fluid sample

The present invention is directed to an electrochemical sensor involving an electrode and a coating that surrounds the electrode, the coating comprising a structural component, a water immiscible solvent, a resistance decreasing component, and an ion exchange component, wherein the coating selectively partitions an electrochemically active drug from a fluid or vapor sample whereby an electrochemical signal within the coating can be measured using the electrode. Devices and methods for using this electrochemical sensor are also disclosed.

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Germantown, TN, United States of America

Erno Lindner