University of Texas System

Orszagos 'frederic Joliot-curie' Sugarbiologiai Es Sugar-egeszsegugyi

Kossuth Lajos Tudomanyegyetem

Magyar Kulkereskedelmi Bank Rt.

Agromen Agrarmenedzseri Kft

Erno Brucher

A Dean Sherry

Laszlo Varga

Istvan Lazar

Ravichandran Ramasamy

Laszlo B Sztanyik

Bela Gyori

Jozsef Emri

Mihaly Torocsik

Odon Kiraly

Bela Kanyar

Zoltan Kovacs

The invention relates to partially novel metal complexes, salts and double salts of 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane compounds of the formula (I), ##STR1## wherein Q.sup.1 and Q.sup.2 mean hydrogen or a group of the formula (III), ##STR2## in the groups of the formula (III) the R subtituents independently represent hydrogen, a C.sub.1-5 straight or branched chain alkyl group, a C.sub.2-5 straight or branched chain alkenyl group, phenyl or phenyl-C.sub.1-5 alkyl group, the two latter ones optionally being substituted on their aromatic part by one or more halogen(s), C.sub.1-5 alkyl, C.sub.1-5 alkoxy, cyano or nitro group(s), with the proviso that at least one of Q.sup.1 and Q.sup.2 is other than hydrogen;

1,4,10,13-tetraoxa-7,16-diazacyclooctadecane derivatives, pharmaceutical

The present invention relates to a new polyazamacrocyclic compound or a salt thereof and its uses. The compound has the formula ##STR1## where x is 2, 3 or a combination of p 2(s) and q 3(s) where p+q=y;

Polyazamacrocyclic compounds for complexation of metal ions

Pharmaceutical composition for decorporating radioactive isotopes from living organisms comprising as active agent a product prepared by reacting 1,4,10,17-tetraoxa-7,16-diazacyclooctadecane with 2-bromomalonic acid disodium salt.

Method for decorporating radioactive isotope from living organism

The present invention relates to a method of using a polyazamacrocyclic compound or a salt thereof to measure intracellular metal ions formula ##STR1## where x is 2, 3 or a combination of p 2(s) and q 3(s) where p +q=y;

Using polyazamacrocyclic compounds for intracellular measurement of

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Debrecen, Hungary

Erno Brucher