Medichem, S.a.

Ernesto Durán López

Jordi Puig Serrano

Juan Contreras Lascorz

Núria Soldevilla Madrid

David Font Gimbernat

Judit Serra Miralles

Rao Lingxiang

Yisong Wen

Zhu Bin

Lingxiang Rao

Jordi Boch I Lladó

The present invention is related to a process for preparing safinamide and salts thereof, preferably safinamide methanesulfonate, with high yields and high enantiomeric and chemical purity without the need of using highly pure intermediates. The process of the present invention is suitable for the production of safinamide and its salts, preferably safinamide methanesulfonate, at industrial scale.

Process for preparing safinamide

The present invention relates to a process for preparing lifitegrast or a salt thereof, wherein the process comprises hydrogenation of compound II in a mixture comprising at least one solvent selected from the group consisting of acetonitrile, a ketone solvent, an ester solvent and a mixture thereof, preferably acetonitrile. 

Process to obtain a tetrahydroisoquinoline derivative

The present invention relates to dabigatran etexilate and related substances and use of the substances as reference standards and markers. There are also provided processes of detecting the substances in samples of dabigatran etexilate, or pharmaceutically acceptable salts or solvates thereof, and also for analyzing the purity of samples of dabigatran etexilate, or pharmaceutically acceptable salts or solvates thereof. There are still further provided processes of preparing dabigatran etexilate and related substances, and pharmaceutical compositions containing the same.

Dabigatran etexilate and related substances, processes and compositions, and use of the substances as reference standards and markers

A process for preparing substituted pyrrolidine compounds, including (5)-2-{1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3-pyrrolidinyl}-2,2-diphenylacetamide hydrobromide, commonly known in the art as darifenacin, comprising reacting a pyrrolidine compound with a benzofuran derivative in the presence of a phase-transfer catalyst.

Method for preparing 1,3-disubstituted pyrrolidine compounds

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Castellbisbal, Spain

Ernesto Durán López