University of Nevada

Wayne State University

Ernesto Abel-Santos

Amber Howerton

Marc Liggins

Norma Ramirez

Christopher Yip

Shiv Sharma

Steven Firestine

Angel Schilke

Jacqueline Phan

Provided herein are compounds, compositions, and methods useful for reducing, preventing, and/or inhibiting germination ofspores, including methods for inhibitinggermination to prevent or treating-associated diseases and disorders such as, for example, severe diarrhea and colitis in a subject. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Inhibitors ofspore germination

Provided herein are materials and methods useful for reducing, preventing, and/or inhibiting germination ofspores, including methods for inhibitinggermination to reduce necrotizing enteritis (NE, also referred to as necrotic enteritis) in animals. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Inhibiting germination of Clostridium perfringens spores to reduce necrotic enteritis

A method of treating a patient to reduce risk of developing Clostridium difficile-associated disease or reducing existing Clostridium difficile-associated disease in a mammalian subject involves administering to a mammalian subject an effective amount of a germination-inhibiting compound derived from taurocholate. Novel compounds of this class are also provided.

Reducing risk of contracting clostridium-difficile associated disease

Inhibiting germination of clostridium perfringens spores to reduce necrotic enteritis

A method of treating a patient to reduce risk of developing-associated disease or reducing existing-associated disease in a mammalian subject involves administering to a mammalian subject an effective amount of a germination-inhibiting compound derived from taurocholate. Novel compounds of this class are also provided.

Materials and methods for stimulating or inhibiting germination ofspores, including methods for inhibitinggermination to reduce foulbrood in honey bees.

Growing community of inventors

Las Vegas, NV, United States of America

Ernesto Abel-Santos