Solvay Enzymes, Inc.

Miles Laboratories, Inc.

Genencor International, Inc.

Ernest W Boyer

Robert L Charles

Graham S Byng

George Boguslawski

Morton Blakeman Ingle

Prophylactic and therapeutic agents for the prevention and treatment of viral-induced tumors and, in particular, compositions derived from an Aspergillus fermentation extract, and the use thereof, either directly or to prepare a medicament, for the prevention and treatment of viral-induced tumors in mammals. Such tumors include papilloma-induced tumors. The composition is topically administered.

Compositions for the prevention and treatment of viral-induced tumors

An alkaline protease which is suitable for detergent formulations is produced by three strains of a species of Bacillus proteolyticus. The alkaline protease has the amino acid terminal sequence of Seq. ID NO.: 1 as follows: Ala-Gln-Ser-Val-Pro-Trp-Gly-Ile-Ser-Arg-Val-Gln-Ala-Pro-Ala-Ala-His-Asn-Ar g-Gly-. In addition, the alkaline protease has a molecular weight of 28 kdaltons, an isoelectric point from 10-11.5, an optimum pH for proteolytic activity at a pH in the range of 8.5 and 11.5, and retains at least 70% of its original activity after being held at a pH of 8.0 at a temperature of 43.degree. C. for a period of 11 days.

Alkaline protease from Bacillus proteolyticus species

Three strains of a species of Bacillus proteolyticus are provided. This bacterium produces an alkaline protease which is suitable for detergent formulations. The alkaline protease has the amino acid terminal sequence of Seq. ID NO.: 1 as follows: Ala-Gln-Ser-Val-Pro-Trp-Gly-Ile-Ser-Arg-Val-Gln-Ala-Pro-Ala-Ala-His-Asn-Ar g-Gly-. In addition, the alkaline protease has a molecular weight of 28 kdaltons, an isoelectric point from 10-11.5, an optimum pH for proteolytic activity at a pH in the range of 8.5 and 11.5, and retains at least 70% of its original activity after being held at a pH of 8.0 at a temperature of 43.degree. C. for a period of 11 days.

Bacillus proteolyticus species which produce an alkaline protease

Method for producing a therapeautic composition for

Alkaline proteases derived from specific bacteria of the species Bacillus proteolyticus have enhanced stability and improved washing ability when blended in general detergents. Also disclosed are new bacteria producing these alkaline proteases. Additionally, there is also disclosed a process for the production of the alkaline proteases which comprises cultivating new bacteria and detergent compositions containing these alkaline proteases.

Alkaline proteases derived from Bacillus proteolyticus

The production of an alkaline serine protease by a soil bacterium, Flavobacterium arborescens is disclosed. Also disclosed is the use of the protease as an enzyme detergent.

Preparation of an alkaline protease from flavobacterium arborescens

An alpha-amylase enzyme having optimum pH activity under alkaline conditions is produced from Bacillus species NRRL-3881. The enzyme is stable in the presence of chelating agents and is useful in producing maltose-containing products.

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Elkhart, IN, United States of America

Ernest W Boyer