Bionano Genomics, Inc.

Ernest Tsz-Tsun Lam

Han Cao

Alex R Hastie

Željko Džakula

According to some embodiments herein, methods and kits for labeling and analyzing nucleic acids are provided. In some embodiments, sequence-specific labeling is performed on polynucleotide sequences associated with a host genome, and the presence or absence of patterns characteristic of extragenomic sequences are determined.

Analysis of polynucleotides

Systems are provided for detecting and quantitating short nucleic acid molecules.

Characterization of molecules in nanofluidics

Methods are provided for detecting and quantitating molecules using fluidics. In preferred embodiments, the methods comprise analyzing blood to detect the presence of circulating DNA or cells from a fetus or tumor.

Methods are provided for characterizing a sample comprising polynucleotide sequences. The methods can comprise labeling nucleic acid molecules of the sample, translocating the plurality of labeled sample nucleic acid molecules though one or more fluidic nanochannels, detecting physical counts of signals from the labeled sample nucleic acid molecule, and determining a copy number of a genome or a fragment or fragments thereof in the sample.

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San Diego, CA, United States of America

Ernest Tsz-Tsun Lam