Bionova Technologies Inc.

Therexcell Pharma Inc.

Ernest Puil

Guy A Dumont

Mihai Huzmezan

Tatjana Zikov

Stéphane Bibian

Craig Robert Ries

Bernard Ansell Macleod

Hossain Cyrus Ahmadi

Bernard A MacLeod

Wei Liu

Thomas Michael Stokes

Hosaain Cyrus Ahmadi

A method and apparatus to monitor the neurologic state of a patient undergoing general anesthesia is provided. Previous automated systems to monitor the neurologic state of a patient undergoing general anesthesia involve a significant time delay between the patient's true hypnotic state and the computed indices. The present invention reduces this time delay by using a different analysis technique applied to spontaneous EEG. A wavelet decomposition and statistical analysis of the observed EEG is conducted and compared to reference data to provide a numerical indicator. In addition, this indicator is more consistent with the patient's loss of consciousness indicated by the loss of count event than previous systems.

Method and apparatus for the estimation of anesthetic depth using wavelet analysis of the electroencephalogram

The invention provides for the use of isovaline or a pharmaceutically acceptable salt thereof for the treatment of Pain in a mammalian subject in some preferred embodiments, the invention provides for the treatment of acute and chronic Pain syndromes where other drug therapies have limited efficacy or unacceptable toxicity in said subject.

Isovaline for treatment of pain

A method and apparatus to monitor and control the anesthesia state of a patient undergoing general anesthesia is provided. Previous automated systems to monitor the anesthesia state of a patient undergoing general anesthesia involve a significant time delay between the patient's true anesthesia state and the computed indices. The present invention reduces this time delay by using a novel analysis technique applied to spontaneous electrophysiological activity. A transformation and statistical analysis of the observed electrophysiological activity is conducted and compared to reference data to provide numerical indicators. In addition, these indicators are consistent with the levels of depression of patients CNS and ANS states. This method is illustrated in detail by CNS monitoring of electroencephalogram signals.

Method and apparatus for the estimation of anesthesia depth

Growing community of inventors

Vancouver, Canada

Ernest Puil