Ionwerks, Inc.

Ernest K Lewis

Thomas F Egan

J Albert Schultz

Kelley L Waters

Steven Ulrich

Kelly L Waters

Methods and devices for mass spectrometry are described, specifically the use of nanoparticulate implantation as a matrix for secondary ion and more generally secondary particles. A photon beam source or a nanoparticulate beam source can be used a desorption source or a primary ion/primary particle source.

Nanoparticulate assisted nanoscale molecular imaging by mass spectrometry

Nanoparticulate assisted nanoscale molecular imaging by mass spectrometery

Nonoparticulate assisted nanoscale molecular imaging by mass spectrometery

The present invention relates to a method and apparatus for ionizing a neutral MALDI desorption plume, and in particular, for efficiently measuring the ionized MALDI desorption plume when post-ionization techniques are combined with a medium pressure MALDI-IM-oTOFMS instrument. Additionally, the present disclosure provides a method and apparatus that simultaneously separates tissue-sample MALDI ions by IM-oTOFMS according to their chemical family. After separation, the MALDI ions are directly compared to the ions created by post-ionizing the co-desorbed neutral molecules with a second laser wherein the second laser is delayed by a few hundred microseconds. The present disclosure further provides novel approaches that enhance the analysis of ions, including the use of giant fullerene internal standards to enhance mass accuracy, and ultraviolet (UV) declustering lasers to generate intact peptides and proteins, either of which may be followed by VUV post-ionization which generates identifiable structural fragments.

Post-ionization of neutrals for ion mobility oTOFMS identification of molecules and elements desorbed from surfaces

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Pearland, TX, United States of America

Ernest K Lewis