Ciphergen Biosystems, Inc.

Biosepra Inc.

Ernest J Woods, Iii

Jonathan L Coffman

Hong Lu

Arthur Magowan

Device and method for processing biological, biochemical or chemical samples are provided wherein a first multiwell plate is stacked atop a second multiwell plate. The first multiwell plate has x wells arranged in a regular array, each capable of receiving a separate sample. Each well of the x wells has an outlet at a lower surface of the first plate. The second multiwell plate has y wells arranged in a regular array, each well of the y wells being capable of receiving a separate sample, and wherein y>x. The outlets at the lower surface of the first multiwell plate are arrayed to register with corresponding inlets of a subset of the y wells of the second multiwell plate when the first plate is stacked atop the second plate. A mechanism for aligning the first plate to the second plate is provided, as well as transfer indicia for tracking transfer of sample from the first plate to the second plate. Also, a mechanism for sealing,the first plate to the second plate is provided so that samples can be directly transferred between the first plate and the second plate without cross-contamination occurring in open wells of the second plate.

Plate alignment and sample transfer indicia for a multiwell multiplate stack and method for processing biological/chemical samples using the same

A sensor for measuring pH and conductivity for liquids is disclosed. The sensor includes a housing having a pH cell and a conductivity cell. A pH fluid flow path is defined between a pH cell fluid inlet and pH cell fluid outlet. An aperture within the pH cell is adapted to receive an electronic pH probe therein. The aperture is configured to position an end of the pH probe having a pH sensing area therein and juxtaposition to the pH fluid flow path so that fluid flowing within the flow path is exposed to the pH sensing area of the electronic pH sensor. A conductivity cell is adapted for placement of a conductivity sensor therein. The conductivity sensor is disposed between a conductivity cell fluid inlet and conductivity cell fluid outlet so that fluid flowing therethrough contacts the conductivity sensor.

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Upton, MA, United States of America

Ernest J Woods, Iii