Other

The University of Chicago

Infectious Disease Research Institute

Paxvax, Inc.

Apicomplexan Therapeutics, LLC

Ernest J Mui

Rima McLeod

Kamal El Bissati

Steven G Reed

Jonathan B Rothbard

Piotr Gornicki

Hong M Moulton

Jeffery L Alexander

Craig Roberts

Fiona Roberts

David Ferguson

William H Witola

Russell Lyons

Jennifer J Johnson

Hua Cong

Michael Kirisits

Doug Mack

Benjamin Samuel

Bo Shiun Lai

Ellen Zuther

William Witola

Jon D Moulton

Tze Guan Tan

Vaccines are disclosed against parasites. The vaccines include peptides in an immunological composition. In particular, the parasite is

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Pharmaceutical formulations of antisense peptide-conjugated phosphorodiamidate morpholino olgomers and methods of use for treatment of apicomplexan infections are disclosed. The invention is particularly directed to treatment ofinfections.

Conjugate constructs, delivery, and use for treatment of disease

This invention relates uses of chorismate synthase, a component components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, in assays to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on chorismate synthase and its inhibitors.

Antimicrobial agents, diagnostic reagents, and vaccines based on unique Apicomplexan parasite components

Growing community of inventors

Chicago, IL, United States of America

Ernest J Mui