Advanced Inhalation Research, Inc.

Civitas Therapeutics, Inc.

Ernest E Penachio

Kevin Stapleton

Lloyd Johnston

Mark Wolff

David A Edwards

Mark DeLong

Craig Dunbar

Richard P Batycky

Charles D Blizzard

Jean C Sung

Jeffrey Mintzes

Blair C Jackson

Lloyd P Johnston

Jeffrey D Mintzes

Marie Elizabeth Chung

Mark Delong

Inhalation device and associated method for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device has a chamber for receiving the receptacle. A ring is circumferentially coupled to an inner surface of the chamber to achieve a higher reproducible emitted dose of medicament from the receptacle. The inhalation device also includes an improved implement for puncturing the receptacle, requiring less force and experiencing fewer failures.

Inhalation device and method

Method and apparatus for producing dry particles. Two liquid components are combined in a static mixer, atomized into droplets, and the droplets dried to form dry particles. Use of the static mixer enables incompatible liquid components to be rapidly and homogeneously combined. The present invention optimizes process conditions for increasing and controlling particle porosity. The present invention also allows for optimization of particle size in real-time during particle production.

Method and apparatus for producing dry particles

Method and apparatus for providing a precisely controlled amount of dry material to a container. In one embodiment, a system is provided for automated container filling. The system includes a container handling mechanism that includes a container block defining a container receptacle, and a cap carrier defining a cap receptacle. The system also includes a dosing portion having a dosing plate defining a dosing hole. The dosing plate is movable between two positions so that when the dosing plate is in the first position the dosing hole is positioned to receive a dose of powder. When the dosing plate is in the second position, the dosing hole is positioned to dispense the dose of powder into the container receptacle.

System for filling containers

Inhalation device

Method and apparatus for providing a precisely controlled amount of dry material to a container. A powder slug is formed, preferably under vacuum, in a dosing hole formed in a dosing plate. The powder slug represents a precisely metered amount of material to be deposited into the container. The dosing plate is translated to a position such that the powder slug is above, and may be expelled into, a container located in a dosing wheel that has been moved into proper position for container filling to occur. In another embodiment, a system is provided for automated container filling.

System, method and apparatus for filling containers

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Cambridge, MA, United States of America

Ernest E Penachio