Bracco Diagnostics Inc.

Bracco Research, USA

Brocco Diagnostics, Inc.

Brocco Research, USA

Bracco Research

Ernest Balestracci

Charles R Quirico

Jacob S Childs

John J Niedospial, Jr

Ernst Schramm

Daniel Darst

Eric Jason Krause

Vishal N Lokhande

Daniel D Darst

Michael N Eakins

Daniel V Clements

Peter B Madson

Julius P Zodda

Jo Anna Monteferrante

James A Melchore, Jr

Rolf E Swenson

Irene K Ropiak

Janet L Gelbach

James A Melchore

John J Niedospial Jr

Jacqueline M Kline

Irene Kucharewicz Ropiak

Infusion system configurations and assemblies facilitate routing of infusion circuit tubing lines. Tubing lines are routed into and out from compartments of a shielding assembly for the infusion system, at locations which prevent kinking and/or crushing of the lines, and/or provide for ease in assembling the circuit. A plurality of the lines may be held together by a support frame to form a disposable infusion circuit subassembly, that can further facilitate routing of the lines.

Infusion system configurations

A shielding assembly for an infusion system includes a plurality of compartments and a door for each compartment, and provides a radioactive radiation barrier for the compartments. One of the compartments contains a radioisotope generator of the infusion system and another of the compartments may contain a waste bottle of the infusion system. An opening into each of the generator and waste bottle compartments may be oriented upward, and the opening into the latter may be at a higher elevation than the opening into the former, for example, to facilitate independent removal and replacement of each. A door of at least one of the compartments, other than the generator compartment, when closed, may prevent the door of the generator compartment from being opened. A cabinet structure for the infusion system may enclose the shielding assembly and secure the generator.

Shielding assemblies for infusion systems

A cabinet structure for an infusion system includes a platform, on which the system is mounted, and a shell surrounding an interior space, which contains at least a portion of the system. The shell preferably includes an opening that is sized and oriented to allow a lowering of a radioisotope generator, for the system, into the interior space, and a lifting of the generator out from the interior space. The shell may further include another opening, located at a higher elevation than the aforementioned opening, in order to provide access to a waste bottle of the infusion system.

Cabinet structure configurations for infusion systems

A radioisotope generator system can include a column assembly having a column, an inlet arm, an outlet arm. The column can contain packing material that binds a radioisotope. In addition, the column may define a notch between an open area and a stopper receptacle area in which an opening of the outlet arm is positioned. In some examples, the system includes a Luer lock connection between the outlet arm and a connector tubing. The Luer lock connection can include a male Luer cap and a female Luer cap each comprising tabs configured to line up with or overlap each other so as to indicate when the caps are sufficiently tightened together so as to form a non-leaking lock.

Containers for pharmaceuticals, particularly for use in radioisotope generators

Shielding assemblies for systems that generate and infuse radiopharmaceuticals. The shielding assemblies include a sidewall that defines several compartments and provides a radiation barrier for the compartments and provides a passageway sized to accommodate routing of an eluate line from a radioisotope generator. One compartment is sized to contain the radioisotope generator. A second compartment is sized to hold a portion of an infusion circuit that may be an extension of the eluate line and may include a waste line and a patient line.

Infusion systems configurations

A removable clamp, for supporting a membrane filter in a medical infusion system, includes connected and opposing walls. A locking feature, which may be connected to an end of one of the walls, engages and disengages a terminal end of the other wall. The filter may be inserted between the opposing walls of the clamp, and an inner surface of each of the opposing walls may be secured against corresponding major surfaces of the inserted filter, by only pressing at least one of the opposing walls of the clamp toward the other of the opposing walls.

Apparatus and methods for support of a membrane filter in a medical infusion system

A removable clamp, for supporting a membrane filter, includes connected and opposing walls. A locking feature, which may be connected to an end of one of the walls, engages and disengages a terminal end of the other wall. When the filter is inserted between the opposing walls of the clamp, and the locking feature engages the terminal end of the other wall, an inner surface of each of the opposing walls is secured against corresponding major surfaces of the inserted filter, in order to support the filter without extending over vent holes of the filter.

Apparatus for support of a membrane filter

The invention is directed to improved containers for pharmaceuticals and any tubing and tubing connectors associated therewith, particularly containers for pharmaceuticals which are irradiated, heated or otherwise subjected to increased pressure. In a preferred embodiment, the invention is directed to an improved container for use in a radioisotope generator, such as a rubidium-82 generator.

Infusion circuit subassemblies

A protective cover and radionuclide generator assembly. The cover protecting inlet and outlet connections disposed on the radionuclide generator. The radionuclide generator having a distal end having a generally flat top surface. The protective cover removably fixed at the distal end and positioned over the generally flat top surface. The protective cover engaging with the radionuclide generator and providing an interference fit. The interference fit preventing the removal of the cover from the radionuclide generator, unless so desired by a user. The cover being made from a radioactive resistant polypropylene.

Protective housing for radionuclide generator and combination thereof

A prefilled syringe of cartridge barrel having a tamper evident closure. Tamper evidence is provided by: a frangible tip seal which is integral with the tapered tip of the barrel; a frangible tip cap covering the tip, the tip seal and a portion of the distal end of the barrel; and an overwrap covering the frangible tip cap and the distal end of the barrel sealed to the distal end of the barrel by a tamper evident seal. The tapered tip is optionally equipped with a luer collar to receive an external luer connector. Alternatively, the tapered tip can be provided with a bore therethrough which can be closed with an elastomeric plug and the external connector can be a tubing conduit.

Growing community of inventors

Iselin, NJ, United States of America

Ernest Balestracci