Nicox S.a.

Dinamite Dipharma S.p.a.

Chemelectiva Srl

Erminio Oldani

Graziano Castaldi

Francesca Benedini

Antonio Tarquini

Gabriele Razzetti

Mauro Gaboardi

Marco Baratella

The present invention relates to a process for the synthesis of cysteamine or a salt thereof.

Process for the preparation of a sulfur-amine

A process for obtaining nitroxyalklesters of the 2(S)(6-methoxy-2-naphthyl)-propanoic acid having an enantiomeric excess higher than or equal to 95%, preferably higher than or equal to 98%, characterized in that an halide of the 2-(S)-(6 methoxy-2-naphthyl)propanoic acid of formula A-Hal, wherein A is the acid acyl residue, is reacted in an inert organic solvent with an aliphatic nitroxyalkanol HO&#x2014;Y&#x2014;ONO, wherein Y is a C-Calkylene or a cycloalkylene from 3 to 8 carbon atoms, or an alkylene as defined containing a cycloalkylene as defined, in the presence of an inorganic base.

Process for the preparation of naproxene nitroxyalkylesters

A novel process for the purification of Pemirolast, whose potassium salt is an anti-allergic pharmaceutical product, is disclosed.

Process for the preparation of high purity Pemirolast

A process for obtaining nitroxyalkylesters of the 2-(S)-(6-methoxy-2-naphthyl)-propanoic acid having an enantiomeric excess higher than or equal to 95%, preferably higher than or equal to 98%, characterized in that an halide of the 2-(S)-(6-methoxy-2-naphthyl)-propanoic acid of formula A-Hal, wherein A is the acid acyl residue, is reacted in an inert organic solvent with an aliphatic nitroxyalkanol HO&mdash;Y&mdash;ONO , wherein Y is a C -C alkylene or a cycloalkylene from 3 to 8 carbon atoms, or an alkylene as defined containing a cycloalkylene as defined, in the presence of an inorganic base.

A process for obtaining (nitroxymethyl)phenyl esters of salicylic acid derivatives of formula (I) wherein R is the OCOR group characterized in that it comprises the following steps: a) reaction of a halide of a salicylic acid derivative with hydroxybenzylacohol in the presence of a base: b) nutration of the obtained product in anhydrous conditions by a mixture of nitric acid with a different inorganic acid, or an organic acid, or an anhydride of one or two organic acids: c) recovery of the final product.

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Novara, Italy

Erminio Oldani