Zambon Group S.p.a.

Newron Pharmaceuticals S.p.a.

Zambon S.p.a.

Ermanno Moriggi

Mauro Napoletano

Franco Pellacini

Andrea Mereu

Fernando Ornaghi

Patricia Salvati

Carla Caccia

Florian Thaler

Gabriele Morazzoni

Alessandra Restivo

Cibele Sabido-David

Laura Faravelli

Roberto Longoni

Carlo Riva

Luciano Pacchetti

Daniela Botta

Stefano Romagnano

Lorenzo Pradella

2-Phenylethylamino substituted carboxamide derivatives and their use as sodium and/or calcium channel modulators useful in preventing, alleviating and curing a wide range of pathologies are presented.

2-phenylethylamino derivatives as calcium and/or sodium channel modulators

2-Phenylethylamino substituted carboxamide derivatives of formula (I); wherein J, W, R, R, R, R, and Rhave the meanings as defined in the specification and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them as active ingredient and their use as sodium and/or calcium channel modulators useful in preventing alleviating and curing a wide range of pathologies, including neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urology, and gastrointestinal diseases where the above mechanisms have been described as playing a pathological role, are described. 

The present invention relates to new pharmaceutical uses of an isoxazolic derivative or a pharmaceutically acceptable salt thereof in the preparation of a medicament useful for treating the neuropathic pain.

Isoxazolic derivative to relieve neuropathic pain

Macrolide compounds endowed with antiinflammatory activity are described, and more particularly macrolide derivatives lacking cladinose in position 3, with antiinflammatory activity, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing them as active ingredient.

Macrolide compounds endowed with antiinflammatory activity

Macrolide compounds of formula (I) wherein X, R, R, R, Rand R, have the meanings as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them as active ingredient and the use thereof in the treatment and prophylaxis of inflammatory diseases, are described. 

Macrolides with antiinflammatory activity

Macrolide compounds lacking cladinose in position 3 having antiinflammatory activity and substantially free of antibiotic properties, pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing them as active ingredient.

Macrolides with anti-inflammatory activity are described. Particularly described are 9a-azalides and their anti-inflammatory activity without cladinose in position 3, the pharmaceutically acceptable salts thereof and the pharmaceutical composition that contain them as active principle.

9a-azalides with anti-inflammatory activity

3&prime;-Des-dimethylamino-9-oxyimino macrolides of formula (I) endowed with anti-inflammatory activity and their pharmaceutical use are described.

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Busto Arsizio, Italy

Ermanno Moriggi