Koninklijke Philips Corporation N.v.

Profound Medical Inc.

Koninkluke Philips N.v.

Erkki Tapani Vahala

Max Oskar Köhler

Shunmugavelu D Sokka

Mika Petri Ylihautala

Teuvo Vaara

Gosta J Ehnholm

Emil George Radulescu

Tero Jouko Valtter Virta

Kumar Raja Gattamaneni

I A Julius Koskela

G&ouml;sta Jakob Ehnholm

Ramon Q Erkamp

Julius Koskela

Thomas Erik Amthor

Peter Forthmann

Romhild Martijn Hoogeveen

Jukka Ilmari Tanttu

Melanie Suzanne Kotys

Lizette Warner

Annemaria Johanna Halkola

Wycliffe Adell Raduma

Kirsi Ilona Nurmilaukas

Marko Tapani Hakkinen

Gösta J Ehnholm

Jaakko Juhani Tölö

Jari Matti Ilmari Salminen

The invention provides for a medical instrument comprising a memory storing machine executable instructions and an image transformation neural network trained for transforming an optical image of a subject into an output image. The output image comprises a pseudo radiographic image. The pseudo radiographic image is aligned with the optical image. The medical instrument further comprises a processor configured to control the medical imaging system. Execution of the machine executable instructions causes the processor to: receive the optical image of the subject and generate the output image by inputting the optical image into the image transformation neural network.

Generation of pseudo radiographic images from optical images

When planning magnetic resonance (MR) guided high intensity focused ultrasonic (HIFU) therapy, HIFU transducer element parameters are optimized as a function of 3D MR data describing a size, shape, and position of a region of interest (ROI) () and any obstructions () between the HIFU transducer elements and the ROI (). Transducer element phases and amplitudes are adjusted to maximize HIFU radiation delivery to the ROI () while minimizing delivery to the obstruction (). Additionally or alternatively, transducer elements are selectively deactivated if the obstruction () is positioned between the ROI () and a given transducer element.

High intensity focused ultrasound transducer optimization

The present disclosure relates to a method for controlling a magnetic resonance imaging guided radiation therapy apparatus () comprising a magnetic resonance imaging system (). The method comprises: acquiring magnetic resonance data using the magnetic resonance imaging system from an organ (), the organ being marked by a predefined marker; the magnetic resonance data comprising 3D image data; identifying in a reconstructed 2D image of the magnetic resonance data at least one signal void candidate of the marker; processing the 3D image data and the identified signal void for calculating a likelihood that the identified signal void candidate is part of the marker; outputting an indication of the calculated likelihood; in response to the outputting, receiving a user input specifying performing a radio therapy; and controlling the irradiation of the organ using the radiation therapy.

Radiotherapy system for accurate locating of 3D objects from magnetic resonance images

It is an object of the invention to improve quality assurance when using MRI images for radiotherapy treatment planning. This object is achieved by a treatment plan evaluation tool A configured for calculating a quality indicator for a radiotherapy treatment plan. The radiotherapy treatment plan originates from a planning image, wherein the planning image is an MRI image acquired under a presence of a main magnetic field having a magnetic field inhomogeneity. The treatment plan evaluation tool is further configured to receive information about the magnetic field inhomogeneity and the treatment plan evaluation tool is further configured to calculate the quality indicator based on the information about the magnetic field homogeneity.

Treatment plan evaluation tool

The invention provides for a medical instrument () comprising: a first display device (), a second display device (), a database (), and a processor (). Execution of instructions cause the processor to: receive () a medical image ('&#x2033;); display () the medical image in a physician graphical user () interface using the first display device and on a technician graphical user interface () using the second display device. Execution of the instructions causes the processor to repeatedly: receive () planning data () from the physician graphical user interface, display () the planning data on the technician graphical user interface; receive () treatment plan data () from the technician graphical user interface; store () the treatment plan data in the database; and generate () control data () for controlling a treatment system using the treatment plan data in the database.

Medical instrument with multiple displays for controlling a treatment system

It is an object of the invention to improve the radiotherapy workflow. This object is achieved by a medical product configured to be used for image based radiotherapy planning. The medical product is configured to be connected to: &#x2014;a medical imaging system configured for acquiring medical images of a patient; &#x2014;a contour module configured for segmenting one or more contours based on one or more of the medical images and; &#x2014;a treatment planning system configured for calculating a radiotherapy plan based on the one or more contours. The medical product comprises a user interface configured to receive user input on a treatment target in the patient and to receive user input on a treatment technique. The medical product is configured to execute a data object readable to the medical imaging system, the contour module and the treatment planning system on the basis of the user input and wherein the data object comprises computer readable instructions for these systems and modules and wherein the systems and modules are configured to contribute to the creation of the radiotherapy plan based on the user input.

Medical product configured to be used for image based radiotherapy planning

A method for controlling a medical apparatus () includes receiving a treatment plan () specifying a target volume () within an imaging volume () and a dose rate of radiation emitted by a radiotherapy apparatus (). The medical apparatus () repeatedly acquires the motion tracking magnetic resonance data and the image magnetic resonance data using an interleaved pulse sequence. The radiotherapy apparatus () is controlled to radiate the target volume () in accordance with the treatment plan (). A dose distribution map descriptive of a radiation dose received by the subject () from the radiotherapy apparatus () is calculated using the motion tracking magnetic resonance data, and the treatment plan (). A diagnostic image is reconstructed using the image magnetic resonance data. A display displays the diagnostic image and the dose distribution map. Treatment plan update data is received from a user interface and the treatment plan () is updated in accordance with the treatment plan update data.

Magnetic resonance guided therapy with interleaved scanning

The present disclosure relates to a therapy system () comprising a radiotherapy device () configured to deliver and direct a radiotherapy beam along an axis to a predefined target position () in an imagine zone () within an MR module () of the therapy system (). The predefined target position () is matched with a position of an RF coil () of the MR module ().

Therapy system containing an MRI module and means for determining the position of an RF coil

A medical apparatus () comprises a high intensity focused ultrasound system () configured for sonicating a target volume () of a subject (). The medical apparatus further comprises a magnetic resonance imaging system () for acquiring magnetic resonance data () from an imaging zone (). The treatment volume is within the imaging zone. The medical apparatus further comprises a memory () containing machine executable, a control module () for controlling the sonication of the target volume using the magnetic resonance data as a control parameter, and a processor (). Execution of the instructions causes the processor to repeatedly acquire () magnetic resonance data in real time using the magnetic resonance imaging system and control () sonication of the target volume by the high intensity focused ultrasound system in real time using the sonication control module and the magnetic resonance data.

Real time control of high intensity focused ultrasound using magnetic resonance imaging

Prior to the radiotherapy, an MR guided radiotherapy device acquires MR data and tracks structures relevant to the radiotherapy treatment. These MR data are displayed to a user. Furthermore, these data are used to calculate a quality factor for the treatment.

Radiation therapy system with real-time magnetic resonance monitoring

A medical apparatus () includes a magnetic resonance imaging system (), a radiation therapy device () having a gantry () and a radiation source (). A radiation detection system () measures radiation detection data () descriptive of a path and intensity of a radiation beam at an intersection of the radiation beam with at least one surface (&#x2033;) surrounding the subject using at least one radiation detector (&#x2033;). Execution of machine readable instructions causes a processor controlling the medical apparatus to: receive () a treatment plan (), acquire () magnetic resonance data () from the imaging zone using the magnetic resonance imaging system, generate () radiation therapy device control commands () using the magnetic resonance data and the treatment plan, irradiate () the target zone by controlling the radiation therapy device using the radiation therapy device control commands, measure () the radiation detection data during irradiation, and determine a time dependent radiation beam path () and a time dependent radiation beam intensity () using the radiation detection data.

Medical apparatus with a radiation therapy device and a radiation detection system

The invention provides for medical instrument () comprising a medical imaging system () for acquiring medical image data () from an imaging zone () and a treatment system () for depositing energy into a treatment zone (). A processor executing instructions receives () a selection of a reference location and one or more anatomical references. The instructions cause the processor to repeatedly: deposit energy into the subject using a treatment system; acquire medical imaging data with the medical imaging system; determine a cumulative dosage data from the medical image data; determine () a first registration () for the reference location; determine () a second registration () for the one or more anatomical references; render () the medical image, the one or more anatomical references, and the cumulative dosage data () in the graphical user interface; and halt the deposition of energy into the subject if a halt command is received from the graphical user interface.

Graphical user interface for medical instruments

A method of using a medical instrument () comprising a magnetic resonance imaging (MRI) system (). The MRI system acquires () first magnetic resonance data () and reconstructs () a first magnetic resonance image (). A registration () of multiple graphical objects () to the first magnetic resonance image is received which defines spatial positions of the multiple graphical objects in the first magnetic resonance image. The method further comprises repeatedly: acquiring () second magnetic resonance data (); reconstructing () a second magnetic resonance image ('); receiving () repositioning coordinates () in the second magnetic resonance image for a first group () selected from the multiple graphical objects; and determining () a coordinate transformation () of a second group () selected from the multiple graphical objects by applying a coordinate transformation model () to the repositioning coordinates.

Coordinate transformation of graphical objects registered to a magnetic resonance image

A diagnostic imaging system () includes a magnetic resonance (MR) imaging system () for providing an image representation of at least a portion of a subject of interest (), a hyperthermia device () for locally heating a target zone within the portion of the subject of interest (), and one or more processors for controlling the MR imaging system () and the hyperthermia device (). Correlating image representations obtained at different temperatures of the target zone provides information on temperature dependent changes of the metabolism of the subject of interest (). A treatment module () applies a treatment to the subject of interest () for destroying cells within the target zone. The one or more processors control the treatment module () for applying the treatment based on diagnostic image representations obtained by the diagnostic imaging system (). Changes of the metabolism of the subject of interest are evaluated to direct a treatment to such areas, where the cells have not yet been destroyed.

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Hyvinkaa, Finland

Erkki Tapani Vahala