Licentia, Ltd.

Karyon-ctt Ltd.

Erkki Koivunen

Stenman Ulf-Hakan

Jari Leinonen

Ale Närvänen

Carl G Gahmberg

Tuula Salo

The present invention relates to novel peptide ligands for prostate specific antigen (PSA) binding specifically with it and enhancing its enzyme activity, to a process for preparation of these peptides, to diagnostic and pharmaceutical compositions comprising these peptides, to the use of these peptides for pharmaceutical and research preparations, to methods using these peptides in diagnostic assays for determination of the concentrations of various molecular forms of PSA, to methods for modulating the PSA enzyme activity and PSA activity dependent conditions by using these peptides either in vivo or in vitro and to the use of these peptides in procedures for biochemical isolation and purification of PSA.

Peptide ligands for prostate specific antigen

The present invention relates to novel peptides which are useful as antagonists of the &#x3b2;integrins, to pharmaceutical compositions comprising these peptides, to the use of the novel peptides for the manufacture of pharmaceutical compositions for the treatment of inflammatory diseases and human leukemias and for inhibiting leukocyte cell adhesion and migration in general, to a method for therapeutic or prophylactic treatment of inflammatory diseases and human leukemias and to the use of the novel peptides as &#x3b2;integrin antagonists for biochemical isolation and purification procedures in vitro.

Peptide ligands of leukocyte integrins

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Helsinki, Finland

Erkki Koivunen