Sionex Corporation

The Charles Stark Draper Laboratory, Inc.

Dh Technologies Development Pte. Ltd.

Sri International

Northeastern University

Renishaw Diagnostics Limited

Erkinjon G Nazarov

Raanan A Miller

Gary Alan Eiceman

Evgeny Krylov

John A Wright

Lawrence A Kaufman

Douglas B Cameron

David B Wheeler

Quan Shi

C James Morris

Anthony D Bashall

Cristina E Davis

Angela M Zapata

Boris Tadjikov

Stephen L Coy

Thomas R Covey

Bradley B Schneider

Paul Vouros

Stephen D Kendig

Clayton Morris

Kenneth A Markoski

Edward T Bullister

Joseph R Stetter

Alexander Hallock

Lawrence H Dubois

Michael J Vestel

Francy Lorena Sinatra

Gareth S Dobson

Michael Coggiola

Muning Zhong

Evgeny Krylova

Clayton J Morris, Ii

Caterina Netti

Spiros Z Manolakos

Richard Copeland

Timothy A Postlethwaite

Daren Levin

An apparatus includes a first electrode and a second electrode. The second electrode is placed in parallel with the first electrode to provide constant gap distance. The gap between the first electrode and the second electrode is at atmospheric pressure. Ions are introduced into the center of the gap and travel through the apparatus in a direction parallel to the first electrode and the second electrode. The apparatus is configured as a high-field symmetric-waveform apparatus for filtering high mobility ions or for fragmenting ions. The apparatus is also configured for three modes of operation: as a conventional DMS; as a filter high mobility ions; and as fragmentation device. A symmetric electric field is produced in the gap with a maximum density normalized field strength greater than 10 Td to filter high mobility ions and with a maximum density normalized field strength greater than 100 Td to fragment ions.

Systems and methods for effective gap filtering and atmospheric pressure RF heating of ions

A method and apparatus for performing differential mobility spectrometer (DMS) which includes decreasing the amount of time that ions spend inside fringing fields generated by the DMS. The apparatus includes an entrance electrode plate sealingly engaged to the entrance of the DMS, and is electrically separated from the parallel plate electrodes of the DMS, the entrance electrode plate has an aperture for allowing the traversal of ions into the DMS; wherein the cross-sectional area of the aperture is less than the cross-sectional area of the ion path, the ion path being located between the two parallel plate electrodes of the DMS. The entrance electrode plate may also have a focusing potential applied to it for focusing of ions.

Jet injector inlet for a differential mobility spectrometer

A non-radioactive plasma ion source device includes at least four planar electrodes that define at least three chambers, including a discharger chamber and at least two additional chambers aligned along a major longitudinal axis of the housing. A discharger ionizes at least one of a transport gas and a discharge gas to form ions in the discharger chamber that are directed by a homogeneous electric field generated by the planar electrodes toward an analyte gas outlet. Ionized species of at least one of the transport gas and the discharge gas that are not entrained by a counterflow gas stream are discharged from the discharger chamber to form a stream of ionized particles that ionize a sample gas and thereby form a stream of ionized analyte particles of the same polarity. The ionized analyte particles are entrained with the stream of ionized particles and pass through an analyte gas outlet to an analyzer.

Non-radioactive, capacitive discharge plasma ion source and method

The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, to sample pre-separation and amplification.

Methods and apparatus for enhanced ion based sample detection using selective pre-separation and amplification

The invention relates generally to systems, methods and devices for analyzing samples and, more particularly, to systems using a mass analyzer in combination with a differential mobility spectrometer to enhance the analysis process of constituents of a sample.

Combined mass and differential mobility spectrometry and associated methods, systems, and devices

A ion mobility-based analyzer system including a first ion mobility-based filter for passing selected ions through a time-varying field where the time-varying field being compensated by an adjustable compensation setting. The analyzer also includes a second ion mobility-based filter for receiving a first portion of ions from the first ion mobility-based filter. The second ion mobility-based filter includes a voltage gradient for separating ions of the first portion of ions where the ions have associated retention times based on their times of flight through the voltage gradient. The second ion mobility-based filter includes a detector for detecting the ions at their retention times. The analyzer system further includes a display that displays the detected ions in a plot relating the retention times of the ions in the second ion mobility-based filter with compensation settings of the first ion mobility-based filter.

Method and apparatus for enhanced ion mobility based sample analysis using various analyzer configurations

The invention relates generally to systems, methods and devices for analyzing samples and, more particularly, to systems using a differential mobility spectrometer in combination with a mass analyzer to enhance the analysis process of constituents of a sample.

Tandem differential mobility spectrometers and mass spectrometer for enhanced analysis

A pre-filter assembly including a differential mobility spectrometer (DMS) that is configured to be in-line with a mass spectrometer (MS) such that the MS continuously receives carrier flow from the DMS when the DMS filtering fields are removed.

Differential mobility spectrometer pre-filter assembly for a mass spectrometer

Detecting and identifying ions using surface enhanced Raman spectroscopy (SERS) and an ion separation pre-filter, such as an ion spectrometer, are provided. The combination of an ion separator as a pre-filter for SERS provides a highly sensitive detector with very low false alarm rates. Target ions from an ionized sample are identified and separated by the ion separator. The target ions are steered and deposited onto a SERS substrate for Raman spectroscopic analysis with an optical probe. The Raman spectrum is compared with reference spectra and the composition of the sample is identified. The ion current from the target ions can also be measured, preferably concurrently with the Raman spectrum measurement. Types of ion separators include a differential ion mobility spectrometer, an ion mobility spectrometer, or a mass spectrometer.

Surface enhanced Raman spectroscopy detection with ion separation pre-filter

The invention relates generally to systems, methods and devices for analyzing samples and, more particularly, to systems using tandem differential mobility spectrometers in combination with a mass analyzer to enhance the analysis process of constituents of a sample.

The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, to sample detection using multiple detection and analytical techniques in combination.

Methods and apparatus for enhanced sample identification based on combined analytical techniques

A compact integrated ion mobility based analysis system includes at least one gas chromatograph (GC) column that receives a sample and elutes constituents of the sample where each of the eluted constituents are temporally separated from each other The system also includes at least one ion mobility based sample analyzer that analyzes the eluted constituents based on their ion mobility characteristics. The system further includes a controller that selectively adjusts the temperature within at least one GC column over a period of time and selectively adjusts the temperature within at least one ion mobility based sample analyzer over a period of time.

Compact gas chromatography and ion mobility based sample analysis systems, methods, and devices

The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, in some embodiments to compact GC-DMS systems, methods, and devices employing enhanced GC column temperature control and configurations to identify various sample constituents.

Explosives detection using differential mobility spectrometry

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Lexington, MA, United States of America

Erkinjon G Nazarov