The Charles Stark Draper Laboratory, Inc.

Massachusetts Eye and Ear Infirmary

Massachusetts Institute of Technology

Erin Pararas

Jeffrey T Borenstein

Ernest Soonho Kim

Michael J McKenna

William Sewell

Jason Oliver Fiering

Mark Joseph Mescher

Sharon G Kujawa

Robert Samuel Langer

Marc Steven Weinberg

Vishal Tandon

Marcello Peppi

Andrew Ayoob

The present disclosure provides compositions and methods for treating an auditory disease in a subject in need thereof comprising administering an effective amount of a gel-based precursor that includes an inner ear-specific therapeutic compound directly into the cochlea of the subject.

Method and process for quantitative evaluation of pharmacokinetics, therapeutic effects and safety of delivery of drug compounds to the inner ear for treatment of auditory disease

An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a bodily cavity of a patient over a period of time includes a drug supply reservoir to supply drug into a delivery channel and an actuator for delivering the drug to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear. The drug is loaded into the delivery channel while producing substantially negligible flow at an outlet of the delivery channel.

Drug delivery apparatus

Growing community of inventors

Swampscott, MA, United States of America

Erin Pararas