University of Houston System

Erin Finley

Richard Coale Willson

Jakoah Brgoch

Andrew Paterson

Disclosed are methods of detecting one or more analytes in a sample by: (1) associating the sample with a surface that includes an analyte binding agent to result in the immobilization of the analytes on the surface; (2) contacting the analyte with a composition that includes at least one phosphor compound with an affinity for the analyte; (3) formation of immobilized analyte binding agent-analyte-phosphor complexes on the surface; (4) separating unbound phosphor compounds from the immobilized complexes; (5) detecting a presence or absence of a luminescence signal from the immobilized complexes; and (6) correlating the luminescence signal to the presence or absence of the analyte in the sample. The phosphor compound may include (SrBa)MgSiO:EuDy, (SrBa)MgSiO:EuDy, (SrBa)MgSiO:EuDy, (SrBa)MgSiO:Eu, and combinations thereof. Additional phosphor compounds may also be utilized, such as [AE]MgSiO:Eu, [AE]AlO:Eu, Dy, and combinations thereof, where AE is at least one of Ca, Sr, or Ba.

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Houston, TX, United States of America

Erin Finley