Waters Technologies Corporation

Erin E Chambers

Martha Degen Stapels

Joanne Mather

Moon Chul Jung

Darryl W Brousmiche

Pamela Carmen Iraneta

Robert Birdsall

Xiaoxiao Liu

Claude R Mallet

Christopher John Hughes

Mary Elizabeth Lame

Stuart A Oehrle

Michael S Young

Yun Wang Alelyunas

Caitlin Dunning

David Dao

Paula Orens

Ziling Lu

Diane Diehl

Jeffrey Mazzeo

The present disclosure relates to a method of analyzing a sample comprising a hydrophobic molecule. The method includes preparing an aqueous solution comprising the sample. The method also includes placing the solution in contact with a polypropylene substrate having a deactivated surface that reduces adsorption of the hydrophobic molecule relative to a polypropylene substrate that has not been deactivated. The method also includes analyzing the sample.

Methods of use for low-bind polypropylene plates and vials

A method for identifying a polypeptide a specimen can include (i) treating a specimen suspected of including an insulin with a base; (ii) extracting a first fraction of the treated specimen by solid phase extraction using a mixed mode or polymeric reversed-phase media and a first solvent including an acid; (iii) separating a component of the first fraction by liquid chromatography using a chromatographic surface including a hydrophobic surface group and one or more ionizable modifiers, and a second solvent including an acid; and (iv) analyzing the component of the first fraction by mass spectroscopy, thereby identifying the polypeptide, if present, using a signal corresponding to a sequence fragment ion from the polypeptide. The signal can correspond to an intact multiply charged precursor fragment selected in a first quadrupole and its corresponding sequence fragment ion selected in a final quadrupole.

Methods for quantifying polypeptides using mass spectrometry

Described is a device for solid phase extraction of a dried sample of a biological fluid. The device includes a support structure such as a plate or support block that has a first side to receive a dried sample card. The support structure also has a second side that is opposite the first side and a number of apertures that extend between the first and second sides. The device also includes a plurality of wells each containing a sample preparation material and having an inlet end that communicates with a respective aperture at the second side of the support structure. Each dried sample on the dried sample card is aligned with one of the apertures. Extraction samples in each well pass through the sample preparation material, such as a chromatographic sorbent, in the well to remove one or more constituents of the extraction sample.

Solid phase extraction device for dried sample cards

Systems, methods and compositions for the purification, separation and analysis of anionic compounds, including polyanionic compounds are disclosed.

Methods for separating and analyzing anionic compounds

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North Brookfield, MA, United States of America

Erin E Chambers