Varian, Inc.

Varian Associates, Inc.

Agilent Technologies, Inc.

Eriks Kupce

The complete structure of a molecule of interest is determined from a single NMR experiment utilizing a single NMR pulse sequence. The experiment utilizes the same pulse sequence for acquiring various one-dimensional and multi-dimensional spectra, with independent receivers tuned to individual resonance frequencies.

Complete structure elucidation of molecules utilizing single NMR experiment

Cycling sidebands arising from broadband decoupling of I-S heteronuclei are separated from the decoupled I spectra investigated in a 2D pulse sequence wherein I excitationis followed after the interval &#x3b4;+twith refocusing &#x3c0; pulseoperating on the I spins. After I excitationthe Jcoupling is inverted by &#x3c0; pulseand immediately following the &#x3c0; pulsedecouplingis turned on and maintained while signal acquisition in the interval tis initiated at &#x3b4;+tafter pulseDouble FT yields a 2D spectrum with sidebands completely displaced to diagonal locii, or alternatively the time domain data may be accumulated into respective tlocations by effectively summing over tto yield a single dimensional spectrum free of cycling sidebands.

Decoupling sideband resolved NMR spectroscopy (desire)

An inversion pulse for wideband application is obtained from a simple nonlinear amplitude modulation wherein the amplitude is modulated in accord with A(t)=A.sub.0 {1-.vertline. sin .beta.t.vertline..sup.n } and the entire pulse is frequency modulated such that the phase varies as .phi.(t)=.phi..sub.0 +1/2 kt.sup.2.

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Oxford, United Kingdom

Eriks Kupce