Shiseido Company, Limited

Eriko Kawai

Yukimitsu Suda

Kenichi Sakuma

Satoshi Tomomasa

Hiroyuki Yokoyama

Norinobu Yoshikawa

Katsuki Ogawa

Mari Yoshida

Yuzo Yoshida

Shigeru Mugikura

Shigeyuki Ogawa

A complex powder comprising an adsorption site and operation site, In the complex powder described above, it is preferable that &#x3b6;-potential of the adsorption site at the pH employed is negative value, And it is preferable that said adsorption site has &#x3b6;-potential at pH7.5 of &#x2212;10 mV or below. In the complex powder described above, it is preferable that said specific enzyme is a plasminogen activator, and the operation site inhibits said plasminogen activator. The complex powder described above can be used as an external composition for improving a rough skin and an external composition for a sensitive skin.

Composite powders and skin preparations for external use containing the same

The objective of this invention is to provide an oily external composition for skin having an excellent rough skin recovering/preventing effect, and wherein powder is well dispersed in oil. An oily external composition for skin of this invention is characterized in that comprising a complex powder (the surface of lipophilic base powder is covered with zinc oxide) and an oil component, wherein said complex powder is dispersed in said oil component, and wherein zeta-potential of said lipophilic base powder is negative value at pH on skin. It is preferable that zeta-potential of said lipophilic base powder is &#x2212;10 mV or less at pH on skin. It is preferable that said lipophilic base powder is swelled in the condition of dispersing in oil. Above-mentioned external composition can be used as a rough skin recovering composition and a sensitive skin caring composition.

Oily skin preparation for external use

A first subject of the present invention is a composite powder having antibacterial and antifungal effect, in which a base powder, zinc oxide and/or zinc basic carbonate, and alkali metal salt are combined. In the composite powder, it is preferable that the base powder is an adsorbing site for adsorbing a specified enzyme, and a site in which zinc oxide and/or zinc basic carbonate and alkali metal salt are combined is an acting site having enzyme inhibiting or activating property. In the composite powder, it is preferable that the zeta-potential of an adsorbing site at pH to be used is a negative value, and the zeta-potential of an adsorbing site at pH 7.5 is &#x2212;10 mV or lower. A second subject of the present invention is a cosmetic composition comprising the aforementioned composite powder. The composite powder can be also used as a skin roughening improving agent, a sensitive skin caring agent or a pimpled skin caring agent.

Composite powder and cosmetic containing the same

The present invention relates to a plasminogen activator inhibitor, an external preparation for skin comprising the same, a method for improving rough skin and in particular, for improvement of an effective inorganic component. A plasminogen activator inhibitor contains a specific zinc oxide which adsorbs a plasminogen activator and effectively inhibits its activity. When it is used as an external preparation for skin, excellent improvement of rough skin is obtainable. Further, when silica-coated zinc oxide is applied as an external preparation for skin, excellent improvement effect and prevention effect for rough skin are obtainable without an intolerance sensitivity reaction in the case of morbid dermatitis such as atopic dermatitis or pimpled skin.

Method for improving morbid dermatitis by inhibiting activity of a plasminogen activator in the skin

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Yokohama, Japan

Eriko Kawai