Central Institute for Experimental Animals

Keio University

Central Institute for Experimental Medicine and Life Science

Erika Sasaki

Takashi Inoue

Hideyuki Okano

Tomoo Eto

Terumi Yurimoto

An excrement property estimation model learning device includes a training data acquisition unit configured to acquire training data including input-side training data including an excrement space which is a predetermined space where there is excrement from an animal being reared, and learning image data that is image data of a captured image obtained by capturing the excrement space, and a correct label indicating whether any abnormal excrement that is abnormal excrement is reflected in an image shown in the learning image data, an excrement property estimation learning model execution unit configured to use an excrement property estimation learning model, which is a machine learning model for estimating a probability that abnormal excrement is reflected in the learning image data, to estimate the probability that abnormal excrement is reflected in the image shown in the learning image data, and an update unit configured to update, on the basis of a difference between an estimation result from the excrement property estimation learning model execution unit and the correct label, the excrement property estimation learning model such that the difference is reduced.

Excrement property estimation model learning device, excrement property estimation device, excrement property estimation model learning method, excrement property estimation method, and program

An object of the present invention is to provide a method for introducing a gene into an embryo for production of a human disease model primate animal using a non-human primate animal such as a marmoset. The present invention relates to a method for introducing a foreign gene into an early embryo of a non-human primate animal, which comprises placing early embryos of a non-human primate in a 0.2 M to 0.3 M sucrose solution, so as to increase the volume of the perivitelline spaces, and then injecting a viral vector containing a human foreign gene operably linked to a promoter into the perivitelline spaces of the early embryos.

Methods for introducing a human gene into a marmoset embryo for making a transgenic marmoset

This invention provides a solution for preserving mammalian early embryos or ES cells by vitrification, which comprises, as a base material, a phosphate buffer that exclusively contains 10% to 15% (v/v) propylene glycol as polyhydric alcohol or a phosphate buffer that exclusively contains 10% to 15% (v/v) propylene glycol and 25% to 35% (v/v) ethylene glycol as polyhydric alcohols and further contains 15% to 25% (v/v) Percoll&#xae; and 0.2 M to 0.5 M sucrose. This invention also provides a method for preserving mammalian early embryos or ES cells by vitrification using such solution.

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Kanagawa, Japan

Erika Sasaki