University of Notre Dame Du Lac

Erika Leemans

Shahriar Mobashery

Mayland Chang

Derong Ding

Edward Spink

Sebastian Testero

Marc Boudreau

The invention provides a newly discovered oxadiazole class of antibiotics. The oxadiazoles impair cell-wall biosynthesis and exhibit activities against the Gram-positive bacteria such as the bacterium, including methicillin-resistant(MRSA) and vancomycin-resistant and linezolid-resistant. For example, 5-(1H-indol-5-yl)-3-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1,2,4-oxadiazole (antibiotic 75b) was efficacious in a mouse model of MRSA infection, exhibiting a long half-life, a high volume of distribution, and low clearance. Antibiotic 75b antibiotic is bactericidal and is orally bioavailable. This class of antibiotics can be used as a therapeutic agent against infections by Gram-positive bacteria such as MRSA.

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Hamme, Belgium

Erika Leemans