Ustav Organicke Chemie a Biochemie Av Cr, V.v.i.

Vysoka Skola Chemicko-technologicka V Praze

Erika Kuzmova

Vishwas Joshi

Vishwas D Joshi

Filip Teply

Miroslav Hajek

Jaroslav Kozak

Michael Jirasek

Manoj R Sonawane

Lukas Severa

Veronika Komarkova

Jana Novotna

Pavla Hubalkova

Paul Eduardo Reyes-Gutierrez

Monoj R Sonawane

Helquat derivatives of general formula I, in which substituents Rand Rare independently selected from a group comprising H and Cto Calkyl, up to three of S, S, Sand Sare present, each of S, S, Sand Sindependently represents a linker consisting of a bivalent hydrocarbon chain having 3-6 carbon atoms, preferably hydrocarbon chain having 4 carbon atoms, and one to four atoms selected from the carbon atoms with the descriptor 2, 4, 2', and 4&#x2032; are substituted with a substituent Rof general formula II, wherein Ris substituted or unsubstituted heteroaryl, Tand Tare independent linkers that bridge atoms Nwith Cand Nwith C, wherein Tand Tindependently represent a bivalent hydrocarbon chain having 2-5 carbon atoms, preferably 2 or 3 carbon atoms; and anions (X)and (X)independently represent anions of pharmaceutically acceptable salts.

Helquats with heteroaromatic substituents, preparation thereof, and use thereof as G-quadruplex stabilizers

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Bratislava, Czechia

Erika Kuzmova