Nestec S.a.

Valio Oy

Other

Dupont Nutrition Biosciences Aps

Mead Johnson Nutrition Company

Oy Aboatech Ab

Societe Des Produits Nestle S.a.

Mjn U.S. Holdings LLC

Erika Isolauri

Seppo Salminen

Kirsi Laitinen

Hannu Korhonen

Arthur Ouwehand

Nina Rautonen

Esa-Matti Lilius

Eeva-Liisa Syvaoja

Leena Mets&auml;niitty

Eeva-Liisa Syv&auml;oja

Leena Metsäniitty

Leena Metsaniitty

The use of probiotic bacteria in the manufacture of a composition for administration to a woman in at least the third trimester of pregnancy for prevention of gestational diabetes, normalizing plasma glucose concentration and/or increasing insulin sensitivity.

Supplemention of maternal diet

The present invention provides probiotic compositions suitable for reducing the incidence and duration of nasal eosinophilia and other parameters associated with birch pollen allergy. In some embodiments, the present invention provides methods and/or compositions suitable for reducing nasal and/or respiratory allergy symptoms. Suitably, such compositions may compriseor both.

Probiotics for use in reducing eosinophilia and respiratory allergies

The present invention is in the field of prophylaxis of allergies, and relates specifically to primary prevention of atopic diseases by administering probiotic bacteria, beneficial microbes of the healthy gut flora, pre- and postnatally to children at high risk of atopic diseases.

Probiotics in primary prevention of atopic diseases

The present invention is directed to a novel method for preventing or treating respiratory infections and acute otitis media in infants. The method comprises the administration of a therapeutically effective amount of astrain and an adherence-promoting probiotic, such as LGG, to the infant.

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Methods and compositions for promoting tolerogenic immune responses or treating immune responses to food antigens compriseGG. Oral administration ofGG to patients such as human infants may promote a tolerogenic immune response to antigens in cow's milk.

Methods of promoting tolerogenic immune responses and compositions therefor

The present invention is in the field of prophylaxis of allergies, and relates specifically to primary prevention of atopic diseases by administering probiotic bacteria, beneficial microbes of the healthy gut flora, pre- and postnatally to children at high risk of atopic diseases. In an embodiment, probiotic bacteria are administered to a pregnant woman at least two weeks before infant delivery and after delivery, probiotic bacteria are administered to the newborn infant for at least two months. The amount of probiotic bacteria administered is about 1&#xd7;10to about 1&#xd7;10colony forming units of the probiotic bacteria.

The present invention provides method of making a protein hydrolysate formula and protein hydrolysate formulas made thereby for downregulating hypersensitivity and for promoting gut immune barrier, and methods of preventing or treating allergies, especially cow's milk allergy by combining the protein with probiotic gastrointestinal bacteria, especially Lactobacilli. The probiotics make it possible to influence the immunological balance, whereby allergy can be prevented by affecting the initiation mechanism of allergy. The present invention makes it possible to develop a person's tolerance of proteins by actively promoting a tolerogenic immune response. In addition, present invention provides for administering fragments of an allergen modified by probiotic gastrointestinal bacteria in order to desensitize a immune response to systemic hyporesponsiveness.

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Nrumijarvi, Finland

Erika Isolauri