Sigilon Therapeutics, Inc.

Erika Ellen Johnston

Robert James Miller

Richard Heidebrecht

Lauren Emily Barney

Michael Beauregard

Omid Veiseh

David Peritt

Justin David Morse

Matthias Alexander Oberli

Paul Kevin Wotton

Guillaume Carmona

Joseph Gordon

Peter Calvin Costello

John Patrick Golden

Faith C David-Hegerich

Devyn McKinley Smith

Jared A Sewell

Owen O'Connor

Francisco Caballero Gonzalez

Devyn Mckinley Smith

Owen O'CONNOR

Described herein are apparatuses and methods for conditioning particles. In some embodiments, the apparatuses and methods are configured for first-in-first-out transit of particles through a chamber containing a conditioning fluid. In some embodiments, the apparatuses and methods of the present disclosure enable the manufacture of particle preparations containing large quantities of particles (e.g., cell-containing particles) with more consistent and improved properties relative to alternative manual processes.

Apparatuses and methods for formation of particles

Described herein are compositions and methods for preparing hydrogel capsules using a cross-linking solution comprising a process additive. The process additive improves the quality of the resulting hydrogel capsules, such as increasing the number of defect-free capsules.

Biocompatible hydrogel capsules and process for preparing same

Described herein are particles comprising a first compartment, a second compartment, and a compound of Formula (I), as well as compositions and methods of making and using the same. The particles may comprise a cell capable of expressing a therapeutic agent useful for the treatment of a disease, disorder, or condition described herein.

Implantable particles and related methods

Growing community of inventors

Cambridge, MA, United States of America

Erika Ellen Johnston