Northwestern University

Cute Lovable Teddy Bear, Llc.

University of California

Erik Pierstorff

Dean Ho

Christian Behrenbruch

Mark Chen

Edward Chow

Houjin Huang

Erik Robinson

Genhong Cheng

Robert Lam

Rafael Shimkunas

Edward K Chow

Xueqing Zhang

The present invention provides various functionalized nanodiamond particles. In particular, the present invention provides soluble complexes of nanodiamond particles and therapeutic agents, for example insoluble therapeutics, anthracycline and/or tetracycline compounds, nucleic acids, proteins, etc. The present invention also provides materials and devices for the controlled release of therapeutics, and methods for uses thereof.

Nanodiamond particle complexes

This invention is in the field of controlled elution devices for therapeutic delivery. There exists a need for a stand-alone capable device for the localized and extended delivery of a therapeutic. This need is overcome by the present invention having an examplary embodiment comprised of a microfilm base (), a reservoir of a therapeutic () disposed about the microfilm base () and a top layer () that is (i) a plurality of laminated layers () of para-xylyelne polymer and/or (ii) para-xylyelne polymer endowed with oxidatively functionalized para-xyele units. The thicknesses of the device is optimally in the range of about 10 to about 200 microns. The device is usable for the localized release of broad spectrum therapeutics for interventional and preventative medicine.

Pary-xylene based microfilm elution devices

This invention is in the field of controlled elution devices for therapeutic delivery. There exists a need for a stand-alone capable device for the localized and extended delivery of a therapeutic. This need is overcome by the present invention having an exemplary embodiment comprised of a microfilm base (), a reservoir of a therapeutic () disposed about the microfilm base () and a top layer () that is (i) a plurality of laminated layers () of para-xylyelne polymer and/or (ii) para-xylyelne polymer endowed with oxidatively functionalized para-xyele units. The thicknesses of the device is optimally in the range of about 10 to about 200 microns. The device is usable for the localized release of broad spectrum therapeutics for interventional and preventative medicine.

Para-xylylene based microfilm elution devices

Disclosed herein are nanofilm coatings for implantable medical devices comprising a diblock or triblock copolymer (PEO-PMMA or PMOXA-PDMS-PMOXA, respectively). Such nanofilms, may be used, for example, as amphiphilic supports for therapeutic agents. These materials are conducive towards the formation of active substrates for a suite of biological and medical applications.

Polymer nanofilm coatings

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Playa Del Ray, CA, United States of America

Erik Pierstorff