Memory Pharmaceuticals Corporation

Memory Pharmaceutical Corporation

F. Hoffmann-La Roche Ag

Erik Mikal Kuester

Ashok Tehim

Hans-Jurgen E Hess

Francisco Xavier Talamas

Richard A Schumacher

Sharada Shenvi Labadie

Allen T Hopper

Robert F Dunn

Ruiping Liu

Joan Marie Caroon

Richard Conticello

Axel Unterbeck

Thomas E Renau

William Frederick Brubaker, Jr

Mike De Vivo

Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with regard to inhibition of other classes of PDEs.

Phosphodiesterase 4 inhibitors

Selective PDE4 inhibition is achieved by 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds like rolipram and show selectivity with regard to inhibition of other classes of PDEs. The compounds of the present invention are of formula I: wherein R, R, and Rare as defined herein.

Selective PDE4 inhibition is achieved by novel compounds, e.g., 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds of the present invention are of formula I: wherein R, R, and Rare as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R, R, Rand Rare as defined herein.

Phosphodiesterase 4 inhibitors, including N-substituted aniline and diphenylamine analogs

Selective PDE4 inhibition is achieved by 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds like rolipram and show selectivity with regard to inhibition of other classes of PDEs. The compounds of the present invention are of formula I:wherein R, R, and Rare as defined herein.

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Rochester, MN, United States of America

Erik Mikal Kuester